2026-01-31_00000085|hard|9K32

Cryo-EM structure of the NbaCas9-guide RNA-target DNA complex; Electron microscopy 2.85Å
Protein #1 736 residues (100% resolved)

GSEKELVLGIAYGGKYTGLGVVDRRNNQVLYARTIKMRDDVADILKGRREQRGIRRTQQTRKKRLRELKKYLNSIGYDNSTELFKSIYSLAHKRGYDYADMPTPEEIEEMDEKEKKEWKDTQRNSRYRKEVLADVRKVMSNGGASDEQIKRVESIFNKQYRPKRFNNRILTKCKVCGKNTPLRRNVRELLLENIVRFLPLESELKETLKRTILEGQQGNINKLFRKLKFNQKDWPGKNLTDIAKNKLPGRLPFCKEHFAENEKFTTIEKSTFRLAPSLKTKIENVLTVIKDEVMPNFALDRVVMESNNFDIAAKTKGKKRLAKEEYSKGHKENRETLMESLLRETDGRCVYCGKTITLADANKDAIYPKKAGGSNIFANLVACCRSCNENKGGRTPSESGIMPNPEVVATIKNDLKKKILDDARSIKQLDFNKYMSHASIGWRHMRDRLKELTGNDKLPVERLSGIVTAYFRRWWGFKKERANDKHHALDAVILASRKDYTDEGLVAMTLKPANSDGREFDPEKHIKESEEFKRNKGSRGSALYDKNPLSIKNGKIARRYMVTEIERGKEDAVISEEWREKLKEAFDRFGVSNGKCLTDLQTKEVGLYGQKNPMSLKCAVRGAGKGQIVLIGNNAFKTNVHNVGVAVYLDEKGKKRACELKNQRLAKHFVEPQDEIKGKILFTLRKGDTVKAEDGNIYRILELGERPVVDIKWVPTSDGKKKRVKTAIHATKLTKL

GSEKELVLGIAYGGKYTGLGVVDRRNNQVLYARTIKMRDDVADILKGRREQRGIRRTQQTRKKRLRELKKYLNSIGYDNSTELFKSIYSLAHKRGYDYADMPTPEEIEEMDEKEKKEWKDTQRNSRYRKEVLADVRKVMSNGGASDEQIKRVESIFNKQYRPKRFNNRILTKCKVCGKNTPLRRNVRELLLENIVRFLPLESELKETLKRTILEGQQGNINKLFRKLKFNQKDWPGKNLTDIAKNKLPGRLPFCKEHFAENEKFTTIEKSTFRLAPSLKTKIENVLTVIKDEVMPNFALDRVVMESNNFDIAAKTKGKKRLAKEEYSKGHKENRETLMESLLRETDGRCVYCGKTITLADANKDAIYPKKAGGSNIFANLVACCRSCNENKGGRTPSESGIMPNPEVVATIKNDLKKKILDDARSIKQLDFNKYMSHASIGWRHMRDRLKELTGNDKLPVERLSGIVTAYFRRWWGFKKERANDKHHALDAVILASRKDYTDEGLVAMTLKPANSDGREFDPEKHIKESEEFKRNKGSRGSALYDKNPLSIKNGKIARRYMVTEIERGKEDAVISEEWREKLKEAFDRFGVSNGKCLTDLQTKEVGLYGQKNPMSLKCAVRGAGKGQIVLIGNNAFKTNVHNVGVAVYLDEKGKKRACELKNQRLAKHFVEPQDEIKGKILFTLRKGDTVKAEDGNIYRILELGERPVVDIKWVPTSDGKKKRVKTAIHATKLTKL
RNA #2 195 bases

GGGGAAAUUAGGUGCGCUUGGCGUUACAGUUAAGGCUCUUUGAAAAUGAUGAUUGAAACGAAAAAAGAGCCUUAAUUGUAAAACGCCUAUAUGAUGAAGGAAUGUACGCUUGGGUUUGUCCAGCCUAAGCCAAACUAAAACUACAGUCGAUAAUGACACCUUCAUUGUGGGUUAGGACAUUAAAAAAAUUUUCAG

GGGGAAAUUAGGUGCGCUUGGCGUUACAGUUAAGGCUCUUUGAAAAUGAUGAUUGAAACGAAAAAAGAGCCUUAAUUGUAAAACGCCUAUAUGAUGAAGGAAUGUACGCUUGGGUUUGUCCAGCCUAAGCCAAACUAAAACUACAGUCGAUAAUGACACCUUCAUUGUGGGUUAGGACAUUAAAAAAAUUUUCAG
DNA #3 43 bases

(DA)(DC)(DC)(DC)(DG)(DT)(DT)(DC)(DC)(DC)(DC)(DG)(DC)(DC)(DA)(DA)(DG)(DC)(DG)(DC)(DA)(DC)(DC)(DT)(DA)(DA)(DT)(DT)(DT)(DC)(DC)(DC)(DC)(DG)(DG)(DG)(DA)(DT)(DC)(DC)(DT)(DC)(DT)

ACCCGTTCCCCGCCAAGCGCACCTAATTTCCCCGGGATCCTCT
DNA #4 43 bases

(DA)(DG)(DA)(DG)(DG)(DA)(DT)(DC)(DC)(DC)(DG)(DG)(DG)(DG)(DA)(DA)(DA)(DT)(DT)(DA)(DG)(DG)(DA)(DC)(DG)(DC)(DG)(DA)(DA)(DC)(DC)(DG)(DG)(DG)(DG)(DG)(DA)(DA)(DC)(DG)(DG)(DG)(DT)

AGAGGATCCCGGGGAAATTAGGACGCGAACCGGGGGAACGGGT
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #6 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference