2026-01-17_00000366|ligand|9U7S

FGFR2 kinase domain with a macrocyclic compound 8r; X-ray diffraction 1.99Å
Protein #1 304 residues (98% resolved)

EYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE

EYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE
Non polymer #2 A1EOJ

InChI=1S/C27H31N7O3/c1-31-8-6-22(7-9-31)33-18-21(16-29-33)23-15-25-28-17-24-19-4-3-5-20(14-19)27(35)32(2)10-11-36-12-13-37-26(23)30-34(24)25/h3-5,14-18,22H,6-13H2,1-2H3

CN1CCC(CC1)n2cc(cn2)c3cc4ncc-5n4nc3OCCOCCN(C(=O)c6cccc5c6)C
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Reference