2026-01-17_00000191|hard|9LME

Checkpoint regulator protein in complex with a nanobody; X-ray diffraction 2.40Å

Protein #1 225 residues (97% resolved)

Raw Sequence ...

HHHHHHENLYFQGLEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQ

Canonical Sequence ...

Protein #2 141 residues (83% resolved)

Raw Sequence ...

MAQVQLVESGGGLVQPGGSLRLSCAASGNTFSTAHMSWVRQAPGKGLEWVSGILSNGAGASYADFVKGRFTISRDSAKNTLYLQMDSLKPEDTAVYYCALGFRTLTGLRGQGTQVTVSSGRYPYDVPDYGSGRAGGGSNQL

Canonical Sequence ...

MAQVQLVESGGGLVQPGGSLRLSCAASGNTFSTAHMSWVRQAPGKGLEWVSGILSNGAGASYADFVKGRFTISRDSAKNTLYLQMDSLKPEDTAVYYCALGFRTLTGLRGQGTQVTVSSGRYPYDVPDYGSGRAGGGSNQL

Non polymer #3 CA

InChI=1S/Ca/q+2

SMILES: [Ca+2]

[Ca+2]

Non polymer #4 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES: C(CO)O

C(CO)O

Non polymer #5 MAN

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1

SMILES: C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O

C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O

Non polymer #6 MG

InChI=1S/Mg/q+2

SMILES: [Mg+2]

[Mg+2]

Non polymer #7 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

SMILES: C(COCCO)O

C(COCCO)O

Non polymer #8 PO4

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3

SMILES: [O-]P(=O)([O-])[O-]

[O-]P(=O)([O-])[O-]

Biounit #1 hetero-2-2-1-1-2-mer

Reference