2026-01-17_00000171|hard|9LIS

CryoEM Structures Uncover the Unexpected Hinges of IscB for Enhanced Gene Editing; Electron microscopy 3.39Å
Protein #1 547 residues (90% resolved)

MAVVYVISKSGKPLMPTTRCGHVRILLKEGKARVVERKPFTIQLTYESAEETQPLVLGIDPGRTNIGMSVVTESGESVFNAQIRTRNKDVPKLMKDRKQYRMAHRRLKRRCKRRRRAKAAGTAFEEGEKQRLLPGCFKPITCKSIRNKEARFNNRKRPVGWLTPTANHLLVTHLNVVKKVQKILPVAKVVLELNRFSFMAMNNPKVQRWQYQRGPLYGKGSVEEAVSMQQDGHCLFCKHGIDHYHHVVPRRKNGSETLENRVGLCEEHHRLVHTDKEWEANLASKKSGMNKKYHALSVLNQIIPYLADQLADMFPGNFCVTSGQDTYLFREEHGIPKDHYLDAYCIACSALTDAKKVSSPKGRPYMVRQFRRHDRQACHKANLNRRYYMGGKLVATNRHKAMDQKTDSLEEYRAAHSAADVSKLTVKHPSAQYKDMSRIMPGSILVSGEGKLFTLRRSEGRNKGQVNYFVSTEGIKYWARKCQYLRNNGGLQIYVKNKGGSGKRPAATKKAGQAKKKKGWSHPQFEKGGGSGGGSGGSAWSHPQFEK

MAVVYVISKSGKPLMPTTRCGHVRILLKEGKARVVERKPFTIQLTYESAEETQPLVLGIDPGRTNIGMSVVTESGESVFNAQIRTRNKDVPKLMKDRKQYRMAHRRLKRRCKRRRRAKAAGTAFEEGEKQRLLPGCFKPITCKSIRNKEARFNNRKRPVGWLTPTANHLLVTHLNVVKKVQKILPVAKVVLELNRFSFMAMNNPKVQRWQYQRGPLYGKGSVEEAVSMQQDGHCLFCKHGIDHYHHVVPRRKNGSETLENRVGLCEEHHRLVHTDKEWEANLASKKSGMNKKYHALSVLNQIIPYLADQLADMFPGNFCVTSGQDTYLFREEHGIPKDHYLDAYCIACSALTDAKKVSSPKGRPYMVRQFRRHDRQACHKANLNRRYYMGGKLVATNRHKAMDQKTDSLEEYRAAHSAADVSKLTVKHPSAQYKDMSRIMPGSILVSGEGKLFTLRRSEGRNKGQVNYFVSTEGIKYWARKCQYLRNNGGLQIYVKNKGGSGKRPAATKKAGQAKKKKGWSHPQFEKGGGSGGGSGGSAWSHPQFEK
RNA #2 190 bases

UAUCAUGGCCGAGGCUCUUCCAACUGAGGGUUGAAAGAGCACAGGCUGAGACAUUCGUAAGGCCGAAAGGCCGGACGCACCCUGGGAUUUCCCCAGUCCCCGGAACUGCAUAGCGGAUGCCAGUUGAUGGAGCAAUCUAUCAGAUAAGCCAGGGGGAACAAUCACCUCUCUGUAUCAGAGAGAGUUUUAC

UAUCAUGGCCGAGGCUCUUCCAACUGAGGGUUGAAAGAGCACAGGCUGAGACAUUCGUAAGGCCGAAAGGCCGGACGCACCCUGGGAUUUCCCCAGUCCCCGGAACUGCAUAGCGGAUGCCAGUUGAUGGAGCAAUCUAUCAGAUAAGCCAGGGGGAACAAUCACCUCUCUGUAUCAGAGAGAGUUUUAC
DNA #3 13 bases

(DC)(DT)(DC)(DA)(DA)(DC)(DC)(DA)(DC)(DC)(DT)(DA)(DC)

CTCAACCACCTAC
DNA #4 17 bases

(DC)(DT)(DA)(DG)(DG)(DT)(DG)(DG)(DT)(DT)(DG)(DT)(DC)(DG)(DG)(DC)(DC)

CTAGGTGGTTGTCGGCC
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #6 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference