2026-01-17_00000006|hard|8UBK

Cryo-EM structure of Ascl1/E12a in complex with NRCAM nucleosome; Electron microscopy 2.60Å
Protein #1 136 residues (71% resolved)

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Protein #2 103 residues (81% resolved)

MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Protein #3 130 residues (84% resolved)

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
Protein #4 126 residues (75% resolved)

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
DNA #5 162 bases

(DG)(DA)(DT)(DC)(DC)(DA)(DT)(DT)(DA)(DC)(DT)(DT)(DC)(DT)(DG)(DA)(DA)(DA)(DC)(DA)(DG)(DA)(DT)(DG)(DA)(DC)(DT)(DC)(DC)(DC)(DA)(DG)(DC)(DA)(DG)(DC)(DT)(DG)(DC)(DT)(DG)(DC)(DC)(DT)(DG)(DT)(DG)(DG)(DC)(DC)(DC)(DA)(DC)(DA)(DG)(DG)(DG)(DC)(DT)(DT)(DC)(DC)(DT)(DG)(DC)(DC)(DC)(DT)(DG)(DC)(DA)(DT)(DG)(DA)(DC)(DA)(DG)(DC)(DT)(DG)(DC)(DA)(DC)(DA)(DT)(DC)(DA)(DC)(DA)(DT)(DC)(DC)(DT)(DG)(DT)(DG)(DG)(DT)(DC)(DA)(DT)(DA)(DC)(DT)(DA)(DC)(DT)(DT)(DC)(DA)(DG)(DC)(DC)(DG)(DC)(DT)(DT)(DC)(DT)(DA)(DC)(DG)(DG)(DC)(DC)(DA)(DG)(DA)(DT)(DA)(DC)(DA)(DA)(DA)(DA)(DG)(DT)(DG)(DG)(DG)(DT)(DG)(DG)(DG)(DG)(DA)(DA)(DC)(DA)(DT)(DA)(DG)(DG)(DC)(DA)(DA)(DG)(DG)(DG)(DA)(DT)(DC)

GATCCATTACTTCTGAAACAGATGACTCCCAGCAGCTGCTGCCTGTGGCCCACAGGGCTTCCTGCCCTGCATGACAGCTGCACATCACATCCTGTGGTCATACTACTTCAGCCGCTTCTACGGCCAGATACAAAAGTGGGTGGGGAACATAGGCAAGGGATC
DNA #6 162 bases

(DG)(DA)(DT)(DC)(DC)(DC)(DT)(DT)(DG)(DC)(DC)(DT)(DA)(DT)(DG)(DT)(DT)(DC)(DC)(DC)(DC)(DA)(DC)(DC)(DC)(DA)(DC)(DT)(DT)(DT)(DT)(DG)(DT)(DA)(DT)(DC)(DT)(DG)(DG)(DC)(DC)(DG)(DT)(DA)(DG)(DA)(DA)(DG)(DC)(DG)(DG)(DC)(DT)(DG)(DA)(DA)(DG)(DT)(DA)(DG)(DT)(DA)(DT)(DG)(DA)(DC)(DC)(DA)(DC)(DA)(DG)(DG)(DA)(DT)(DG)(DT)(DG)(DA)(DT)(DG)(DT)(DG)(DC)(DA)(DG)(DC)(DT)(DG)(DT)(DC)(DA)(DT)(DG)(DC)(DA)(DG)(DG)(DG)(DC)(DA)(DG)(DG)(DA)(DA)(DG)(DC)(DC)(DC)(DT)(DG)(DT)(DG)(DG)(DG)(DC)(DC)(DA)(DC)(DA)(DG)(DG)(DC)(DA)(DG)(DC)(DA)(DG)(DC)(DT)(DG)(DC)(DT)(DG)(DG)(DG)(DA)(DG)(DT)(DC)(DA)(DT)(DC)(DT)(DG)(DT)(DT)(DT)(DC)(DA)(DG)(DA)(DA)(DG)(DT)(DA)(DA)(DT)(DG)(DG)(DA)(DT)(DC)

GATCCCTTGCCTATGTTCCCCACCCACTTTTGTATCTGGCCGTAGAAGCGGCTGAAGTAGTATGACCACAGGATGTGATGTGCAGCTGTCATGCAGGGCAGGAAGCCCTGTGGGCCACAGGCAGCAGCTGCTGGGAGTCATCTGTTTCAGAAGTAATGGATC
Protein #7 270 residues (84% resolved)

MKSSHHHHHHENLYFQSNAMDIKMTQSPSSMHASLGERVTITCKASQDIRSYLSWYQQKPWKSPKTLIYYATSLADGVPSRFSGSGSGQDFSLTINNLESDDTATYYCLQHGESPYTFGSGTKLEIKRAGGGGSGGGGSGGGGSGGGGSMEVQLQQSGPELVEPGTSVKMPCKASGYTFTSYTIQWVKQTPRQGLEWIGYIYPYNAGTKYNEKFKGKATLTSDKSSSTVYMELSSLTSEDSAVYYCARKSSRLRSTLDYWGQGTSVTVSS

MKSSHHHHHHENLYFQSNAMDIKMTQSPSSMHASLGERVTITCKASQDIRSYLSWYQQKPWKSPKTLIYYATSLADGVPSRFSGSGSGQDFSLTINNLESDDTATYYCLQHGESPYTFGSGTKLEIKRAGGGGSGGGGSGGGGSGGGGSMEVQLQQSGPELVEPGTSVKMPCKASGYTFTSYTIQWVKQTPRQGLEWIGYIYPYNAGTKYNEKFKGKATLTSDKSSSTVYMELSSLTSEDSAVYYCARKSSRLRSTLDYWGQGTSVTVSS
Protein #8 231 residues (27% resolved)

MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
Protein #9 651 residues (12% resolved)

MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGTQFAGSGLEDRPSSGSWGSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVADGSLHPSAELWSTPSQVGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLHGSEVNGSLPAVSSFSAAPGTYSGTSGHTPPVSGAAAESLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFTGPMSLGGRHAGLVGGSHPEEGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSYSGLGRAGTTAGASEIKREEKEDEEIASVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL

MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGTQFAGSGLEDRPSSGSWGSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVADGSLHPSAELWSTPSQVGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLHGSEVNGSLPAVSSFSAAPGTYSGTSGHTPPVSGAAAESLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFTGPMSLGGRHAGLVGGSHPEEGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSYSGLGRAGTTAGASEIKREEKEDEEIASVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL
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