2026-01-10_00000189|ligand|9FRS

Human PARP10 ART domain bound to a phthalazinone-based inhibitor; X-ray diffraction 2.02Å
Protein #1 198 residues (97% resolved)

MKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFAKRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHAHHH

MKGPWNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFAKRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHAHHH
Non polymer #2 A1IFC

InChI=1S/C25H20FN7O2S/c1-14-12-32(13-21-29-30-22(33(14)21)24-27-8-9-36-24)25(35)18-10-15(6-7-19(18)26)11-20-16-4-2-3-5-17(16)23(34)31-28-20/h2-10,14H,11-13H2,1H3,(H,31,34)/t14-/m1/s1

C[C@@H]1CN(Cc2n1c(nn2)c3nccs3)C(=O)c4cc(ccc4F)CC5=NNC(=O)c6c5cccc6
Non polymer #3 ACT

InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1

CC(=O)[O-]
Non polymer #4 CL

InChI=1S/ClH/h1H/p-1

[Cl-]
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Reference