2025-12-13_00000269|ligand|9VRR

Crystal structure of human PTPN2 with inhibitor WS3; X-ray diffraction 1.95Å
Protein #1 301 residues (99% resolved)

GPLGSPWGSIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKED

GPLGSPWGSIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKED
Non polymer #2 A1ETL

InChI=1S/C16H22FN3O4S/c1-10(2)3-4-19-7-12(8-19)11-5-13(17)16(14(21)6-11)20-9-15(22)18-25(20,23)24/h5-6,10,12,21H,3-4,7-9H2,1-2H3,(H,18,22)

CC(C)CCN1CC(C1)c2cc(c(c(c2)F)N3CC(=O)NS3(=O)=O)O
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Reference