2025-12-13_00000199|medium|9PQ2

Cryo-EM structure of HIV-1 459C-WT DS-SOSIP RnS Env trimer; Electron microscopy 3.33Å
Protein #1 487 residues (95% resolved)

GNLWVTVYYGVPVWREAKTTLFCASDAKAYDREVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNVTSSAANVTSNVTNDANNASNANGRNVINEDMKNCSFNATTEIRDRKKEMYALFYKLDIVPLDGEKSDNRYRLINCNTSTITQACPKVSFDPIPIHYCTPAGFAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEDIIIRSENLTNNAKTIIVHLNESVEIVCTRPNNMTRKSIRIGPGQTFYALNDIIGDIRQAHCNISEEKWNNTLHRVWKKLVEHFPNKTTIRFDRHSGGDLEITTHSFNCGGEFFYCNTSGLFNITYNSNYTYNDTKHNGTKVITLPCRIKQIINMWQEVGRAMYAPPIAGNITCTSNITGLLLTRDGGNNSTETETFRPGGGDMRDNWRSELYKYKVVEIKPLGIAPTGCKRRVVER

GNLWVTVYYGVPVWREAKTTLFCASDAKAYDREVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNVTSSAANVTSNVTNDANNASNANGRNVINEDMKNCSFNATTEIRDRKKEMYALFYKLDIVPLDGEKSDNRYRLINCNTSTITQACPKVSFDPIPIHYCTPAGFAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEDIIIRSENLTNNAKTIIVHLNESVEIVCTRPNNMTRKSIRIGPGQTFYALNDIIGDIRQAHCNISEEKWNNTLHRVWKKLVEHFPNKTTIRFDRHSGGDLEITTHSFNCGGEFFYCNTSGLFNITYNSNYTYNDTKHNGTKVITLPCRIKQIINMWQEVGRAMYAPPIAGNITCTSNITGLLLTRDGGNNSTETETFRPGGGDMRDNWRSELYKYKVVEIKPLGIAPTGCKRRVVER
Protein #2 153 residues (82% resolved)

AVGIGAVFLGFLGAAGSTMGAASNTLTVQARQLLSGIVQQQSNLPKAPEAQQHLLQLTVWGIKQLQTRVLAIERYLEVQQLLGLWGCSGKLICCTAVPWNSSWSNKSETEIWNNMTWMQWDREINNYTNTIYRLLEESQFQQEINEVDLLALD

AVGIGAVFLGFLGAAGSTMGAASNTLTVQARQLLSGIVQQQSNLPKAPEAQQHLLQLTVWGIKQLQTRVLAIERYLEVQQLLGLWGCSGKLICCTAVPWNSSWSNKSETEIWNNMTWMQWDREINNYTNTIYRLLEESQFQQEINEVDLLALD
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference