2025-12-13_00000198|medium|9PNU

Cryo-EM structure of K001-A1 Fab in complex with HIV-1 459C-OPT RnS DS-SOSIP Env trimer; Electron microscopy 3.01Å
Protein #1 246 residues (97% resolved)

QVQLQQWGEGLVKPSETLSLTCAVYGGSISGDYYWTWIRQPPGMGLEWIGYIYGDTASTNYNPSLKNRVTISKDTSKNQFSLKLDSVTAADTAVYYCARECGGQQVLHDDD(TYS)DFYDPTIGLDSWGQGVVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ

QVQLQQWGEGLVKPSETLSLTCAVYGGSISGDYYWTWIRQPPGMGLEWIGYIYGDTASTNYNPSLKNRVTISKDTSKNQFSLKLDSVTAADTAVYYCARECGGQQVLHDDDYDFYDPTIGLDSWGQGVVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ
Protein #2 220 residues (100% resolved)

DIVMTQTPLSLPVTPGEPASISCRSSQSLLDSGDGNTYLDWYLQKPGQSPQPLIYEVSNRASGVPDRFSGSGSDTDFTLRIRKVEAEDVGVYYCMQYTHIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

DIVMTQTPLSLPVTPGEPASISCRSSQSLLDSGDGNTYLDWYLQKPGQSPQPLIYEVSNRASGVPDRFSGSGSDTDFTLRIRKVEAEDVGVYYCMQYTHIPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Protein #3 179 residues (72% resolved)

AVGIGAVFLGFLGAAGSTMGAASNTLTVQARQLLSGIVQQQSNLLKAPEAQQHLLQLGVWGFKQLQTRVLAIERYLEVQQLLGLWGCSGKLICCTAVPWNSSWSNKSETEIWNNMTWMQWDREISNYTNTIYRLLEESQFQQEINEKDLLALDGGGLVPQQSGGLNDIFEAQKIEWHEG

AVGIGAVFLGFLGAAGSTMGAASNTLTVQARQLLSGIVQQQSNLLKAPEAQQHLLQLGVWGFKQLQTRVLAIERYLEVQQLLGLWGCSGKLICCTAVPWNSSWSNKSETEIWNNMTWMQWDREISNYTNTIYRLLEESQFQQEINEKDLLALDGGGLVPQQSGGLNDIFEAQKIEWHEG
Protein #4 470 residues (96% resolved)

GPNLWVTVYYGVPVWREAKTTLFCASDAKAYDREVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLECTAFNSSSHTNSSIAMQEMKNCSFNMTTELRDKKKKVSALFYKLDIVPLNKNGRQYRLINCNTSTCTQICPKVSFDPIPIHYCTPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEDIIIRSENLTNNAKTIIVHLNESVEIVCIRPNNMTRKSIRIGPGQTFYALNDIIGDIRQPHCNISKEKWNNTLHRVWKKLVEHFPNKTIIFFDRHSGGDLEITTHSFNCGGEFFYCNTSGLFNITYNSNYTYNDTKHNGTKVITLPCRIKQIINMWQEVGRCMYAPPIAGNITCTSNITGLLLTRDGGNNSTETETFRPGGGDMRDNWRSELYKYKVVEIKPLGIAPTGCKRRVVER

GPNLWVTVYYGVPVWREAKTTLFCASDAKAYDREVHNVWATHACVPTDPNPQEIVLENVTENFNMWKNDMVDQMHEDIISLWDQSLKPCVKLTPLCVTLECTAFNSSSHTNSSIAMQEMKNCSFNMTTELRDKKKKVSALFYKLDIVPLNKNGRQYRLINCNTSTCTQICPKVSFDPIPIHYCTPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEDIIIRSENLTNNAKTIIVHLNESVEIVCIRPNNMTRKSIRIGPGQTFYALNDIIGDIRQPHCNISKEKWNNTLHRVWKKLVEHFPNKTIIFFDRHSGGDLEITTHSFNCGGEFFYCNTSGLFNITYNSNYTYNDTKHNGTKVITLPCRIKQIINMWQEVGRCMYAPPIAGNITCTSNITGLLLTRDGGNNSTETETFRPGGGDMRDNWRSELYKYKVVEIKPLGIAPTGCKRRVVER
Non polymer #5 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Download coordinates
Reference