2025-12-13_00000093
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ligand
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9L13
The crystal structure of SARS-CoV-2 Main protease in complex with an iso-quinoline-derived inhibitor FD6-31;
X-ray diffraction 1.96Å
Protein #1
301 residues (100% resolved)
Raw Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS
Canonical Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS
Non polymer #2
A1EH0
InChI=1S/C22H19ClN2O2/c23-17-6-5-16-14-27-22(20(16)11-17)7-9-25(10-8-22)21(26)19-13-24-12-15-3-1-2-4-18(15)19/h1-6,11-13H,7-10,14H2
InChI=1S/C22H19ClN2O2/c23-17-6-5-16-14-27-22(20(16)11-17)7-9-25(10-8-22)21(26)19-13-24-12-15-3-1-2-4-18(15)19/h1-6,11-13H,7-10,14H2
SMILES: c1ccc2c(c1)cncc2C(=O)N3CCC4(CC3)c5cc(ccc5CO4)Cl
c1ccc2c(c1)cncc2C(=O)N3CCC4(CC3)c5cc(ccc5CO4)Cl
Biounit #1
homo-dimer
Download coordinates
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Model
Reference
100%