2025-11-29_00000138|ligand|9NK6

Thermothelomyces thermophilus SAM complex closed conformation; Electron microscopy 2.88Å
Protein #1 334 residues (93% resolved)

MSASIPSAAPSWRKMQIPRPLQRLFDYFPLRIYEPNELPERSQQLTSGDLPTLYVFSTDSDARLGLPSFNPGCLKWQTLLRLANLDFRILPSTNHSSPTGSLPFLLPPRTSPTASPAPIPASGLLSFARKNPWRPGKAADLDLGHLDADLPPRAQAYLALITHSLRNAWLCALYLDPTHDALLRRLYVDPASSSRAVRAALLHQLRRAAAEQVATASSGGGKIVSLAPVDSADGIDEEAVYRSARDALDALASLLRESETAWFFGTERPGSFDAALFSYTHLMVEYMSEEEDTESAKGRVSLGRMVKEAGNGELAEHRERMLGVAWPEWDGYRR

MSASIPSAAPSWRKMQIPRPLQRLFDYFPLRIYEPNELPERSQQLTSGDLPTLYVFSTDSDARLGLPSFNPGCLKWQTLLRLANLDFRILPSTNHSSPTGSLPFLLPPRTSPTASPAPIPASGLLSFARKNPWRPGKAADLDLGHLDADLPPRAQAYLALITHSLRNAWLCALYLDPTHDALLRRLYVDPASSSRAVRAALLHQLRRAAAEQVATASSGGGKIVSLAPVDSADGIDEEAVYRSARDALDALASLLRESETAWFFGTERPGSFDAALFSYTHLMVEYMSEEEDTESAKGRVSLGRMVKEAGNGELAEHRERMLGVAWPEWDGYRR
Protein #2 532 residues (86% resolved)

MSHHHHHHHHHHGSENLYFQSASSLGFGGSNAVDKVNATTTPGTVATPNSGPTKMLDEHILTPASISTLEVHGATNTRRSLLDQIFKPVLEDTAAAGTTLGQVLDRVGAATKKLARFDIFKEEGFGVFLSEAAPPQSAPPTDRTDLDISIRVKEKSRLVFSAGTDFGNAEGSAYTNAVVRNIFGGAETLTVNASTGTRTRSAYNATFSTPINGNPDLRLSVEALRSATQKPWASHEEHLTGANLRLAWLTEKGDTHALAYSSVWRQLTGLAPTASPTVRADAGDSLKSSLTHTFTRDRRDNPMLPQSGYLFRSVSELAGWGPLNGDVSFAKTEVEASGALPVAIPGLAGKSGVSVGGGLRLGVLYPLPLGYSLTGAAQPSRINDRFQLGGPNDVRGFKIGGLGPHDGVDAVGGDVFAAGSVNALLPLPRTGPDSPLRLQLYANAGRLVALNSKGTDKEGKEGLAMDSAAVFKGVKSAVGKLTNGIPSLAAGVGLVYAHPVARFELNFSLPLVLRRGEEGRKGLQVGVGISFL

MSHHHHHHHHHHGSENLYFQSASSLGFGGSNAVDKVNATTTPGTVATPNSGPTKMLDEHILTPASISTLEVHGATNTRRSLLDQIFKPVLEDTAAAGTTLGQVLDRVGAATKKLARFDIFKEEGFGVFLSEAAPPQSAPPTDRTDLDISIRVKEKSRLVFSAGTDFGNAEGSAYTNAVVRNIFGGAETLTVNASTGTRTRSAYNATFSTPINGNPDLRLSVEALRSATQKPWASHEEHLTGANLRLAWLTEKGDTHALAYSSVWRQLTGLAPTASPTVRADAGDSLKSSLTHTFTRDRRDNPMLPQSGYLFRSVSELAGWGPLNGDVSFAKTEVEASGALPVAIPGLAGKSGVSVGGGLRLGVLYPLPLGYSLTGAAQPSRINDRFQLGGPNDVRGFKIGGLGPHDGVDAVGGDVFAAGSVNALLPLPRTGPDSPLRLQLYANAGRLVALNSKGTDKEGKEGLAMDSAAVFKGVKSAVGKLTNGIPSLAAGVGLVYAHPVARFELNFSLPLVLRRGEEGRKGLQVGVGISFL
Protein #3 484 residues (73% resolved)

MSSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKENLYFQGGAVQLHVWGPAFGLPSIDAECLAAIAYLAQTLGSADYQLIQSSPSAVPTQHLPTLYDSRTSTWIGGFTSITAHLHTHPPPTFQSAPQPTDGSSSTTTTTTTTTTAASATADGTAYTAFLSAHAAPLLALSLYVSSANYGAATRPAYSAVLPLPLPWTEPPAVRAAMARRAAHLGLSSLDADAAAERARAEERRAAADGWVAVPPHATAGRAAGGGGGGGGGGGKGGGVAAVLTPEQKSRIRLEEAAREVLDVLAEVDWAAGGGGRQVAAEVRCLAFGYLALMLLPDVPRPWLREIMEGRYPALCTFVRDFRARVFPQGGKLLPWADGGAQASASASASASAVALRFVRAVMAEVPLVGEWWSRWWTARKKREVLASKGAKPAPSNDLLLLLGAGLGLTVVGAGVFFYRGLPPFGEAVQVWRKPVVGLSSFGAAGAMFSGALYGLD

MSSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKENLYFQGGAVQLHVWGPAFGLPSIDAECLAAIAYLAQTLGSADYQLIQSSPSAVPTQHLPTLYDSRTSTWIGGFTSITAHLHTHPPPTFQSAPQPTDGSSSTTTTTTTTTTAASATADGTAYTAFLSAHAAPLLALSLYVSSANYGAATRPAYSAVLPLPLPWTEPPAVRAAMARRAAHLGLSSLDADAAAERARAEERRAAADGWVAVPPHATAGRAAGGGGGGGGGGGKGGGVAAVLTPEQKSRIRLEEAAREVLDVLAEVDWAAGGGGRQVAAEVRCLAFGYLALMLLPDVPRPWLREIMEGRYPALCTFVRDFRARVFPQGGKLLPWADGGAQASASASASASAVALRFVRAVMAEVPLVGEWWSRWWTARKKREVLASKGAKPAPSNDLLLLLGAGLGLTVVGAGVFFYRGLPPFGEAVQVWRKPVVGLSSFGAAGAMFSGALYGLD
Non polymer #4 ERG

InChI=1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1

CC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3C2=CC=C4[C@@]3(CC[C@@H](C4)O)C)C
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