2025-11-22_00000159|hard|9LQ5

Cryo-EM structure of Apo type III-B CRISPR-Cas effector complex; Electron microscopy 2.97Å
Protein #1 469 residues (100% resolved)

MNQLTAILKQHTPMIHFQHNESGATLRASEVKPLLDKFILTKLGNGDIREGRLYAKKNNWLIDNEKNYALNYKLSISLQKKSRLEYLITSSTFPLPTERPSNFFTIQNSPYFAQEKCVGINTNSTIILKKSNSDPRKKEAEFKEKNWSQIDKKGLEWQDFTIKIFSLKGDLINKIQTYLPAFFICHNFGTRNNKGFGSFTVEYINNQKNICNVEDTLKENFAFVYKKKIALSRQSTLDFIYIYNQIFSTIKKDYQILKSGYNFRNEYIKSLLFCYFVSKYPNYRWEKRKMKQLIKARGYELKGDHSPISGIRENDNSWNDPNPNGYNYAYIRAILGLAEQYEFQLETPYQKAIVKIKSANNCISRYKSPLLFKIINNSIYLVGNEINTEILNKPFQYSYIEQTKNKNMRTGKSEITERTMHINEIEMNYKNRINYHYTPTSFSLIDFMQYAMSYKKNGKNILNYIPLKQ

MNQLTAILKQHTPMIHFQHNESGATLRASEVKPLLDKFILTKLGNGDIREGRLYAKKNNWLIDNEKNYALNYKLSISLQKKSRLEYLITSSTFPLPTERPSNFFTIQNSPYFAQEKCVGINTNSTIILKKSNSDPRKKEAEFKEKNWSQIDKKGLEWQDFTIKIFSLKGDLINKIQTYLPAFFICHNFGTRNNKGFGSFTVEYINNQKNICNVEDTLKENFAFVYKKKIALSRQSTLDFIYIYNQIFSTIKKDYQILKSGYNFRNEYIKSLLFCYFVSKYPNYRWEKRKMKQLIKARGYELKGDHSPISGIRENDNSWNDPNPNGYNYAYIRAILGLAEQYEFQLETPYQKAIVKIKSANNCISRYKSPLLFKIINNSIYLVGNEINTEILNKPFQYSYIEQTKNKNMRTGKSEITERTMHINEIEMNYKNRINYHYTPTSFSLIDFMQYAMSYKKNGKNILNYIPLKQ
Protein #2 600 residues (99% resolved)

MKYIAITLGPITRTIEMAESTKELWAASYFFSYLAKKIVEPFVKKNRTFQLPLINEEMQKPHCGAGLFPDRYIFKSEPGDLELLKQHSDQVLIEIAGHIASPSLPGTAKDVSQIYHYLKSYIKIYFIERTLESDDPHVVIPACEKYLNIIENQETFPEQEETMISHQKSDFLKFLITNVNGKIYRKDKNSIPRFTGSFLTRDAFGDMNGERLFESILEISASELNINIQQKALEVITANEKNKGEKYSDQIWDAEEIILNDNKAQLRPYHKYIAIIKSDGDSMGETIKSMGAYNIPITQLSKALLSFNIESINEIVAYGGKPIFIGGDDLLCFAPVCCNGNNVFNLVEKLSTCFDQCINQHLQQYINACSEAQRPLPSLSFGISITYHKYPMFEALHTTDYLLEMVAKDNLFKYTLSNKNILNENMKRFILKNKLAFSLQKHSGQIYHTAMSKKGKSYVKFNMLLQKYILKNKDMSKTQESEKFLSSVIQMIRAHAEILQIILQNEDKRTEMLKNYFDNNFNESCHLGYTGLFEDIQTLLCLRYQENIQDYQNRNEIIQQNTILTSDEKEILIVSPAMDAIHTIFTALQFIHFINYNKDE

MKYIAITLGPITRTIEMAESTKELWAASYFFSYLAKKIVEPFVKKNRTFQLPLINEEMQKPHCGAGLFPDRYIFKSEPGDLELLKQHSDQVLIEIAGHIASPSLPGTAKDVSQIYHYLKSYIKIYFIERTLESDDPHVVIPACEKYLNIIENQETFPEQEETMISHQKSDFLKFLITNVNGKIYRKDKNSIPRFTGSFLTRDAFGDMNGERLFESILEISASELNINIQQKALEVITANEKNKGEKYSDQIWDAEEIILNDNKAQLRPYHKYIAIIKSDGDSMGETIKSMGAYNIPITQLSKALLSFNIESINEIVAYGGKPIFIGGDDLLCFAPVCCNGNNVFNLVEKLSTCFDQCINQHLQQYINACSEAQRPLPSLSFGISITYHKYPMFEALHTTDYLLEMVAKDNLFKYTLSNKNILNENMKRFILKNKLAFSLQKHSGQIYHTAMSKKGKSYVKFNMLLQKYILKNKDMSKTQESEKFLSSVIQMIRAHAEILQIILQNEDKRTEMLKNYFDNNFNESCHLGYTGLFEDIQTLLCLRYQENIQDYQNRNEIIQQNTILTSDEKEILIVSPAMDAIHTIFTALQFIHFINYNKDE
Protein #3 423 residues (87% resolved)

MSHHHHHHHHDGKPIPNPLLGLDSTGSDQTENSGENLYFQGANAMNRHYLITLTPMDWFFFGGERTLDDGKSADYISHSNKFPQQSALLGMIRYQLLKQHNLLSQFPYTENKPTEKEIMKTLIGEQSFRMTERKAKSLGLGVIKQISPLMLIECKDDTSSRSIYFPLPLDDGYKVSFNETSNEDKVFYNGIECPIPNVYPASEEQDSGNQKRKFFDHKTYNNYLFWCTQGNNQIKKLLSDEIWISKMQIGITKHVEEGEDNDKSFYKQEFLQLKKSFIYAFYITLSGESELSSDIIQLGGQRSVFRMEVESIEENSDIQEKYQTAAQFLTQSDRLLILSPTYVDNLKELSALCNFMWSDSIVFRNIQTTNASNFYGKPIKSSSKYHFLKPGSVLYFKQGKRKEVEKLLMDYTYLRLSGYNIYI

MSHHHHHHHHDGKPIPNPLLGLDSTGSDQTENSGENLYFQGANAMNRHYLITLTPMDWFFFGGERTLDDGKSADYISHSNKFPQQSALLGMIRYQLLKQHNLLSQFPYTENKPTEKEIMKTLIGEQSFRMTERKAKSLGLGVIKQISPLMLIECKDDTSSRSIYFPLPLDDGYKVSFNETSNEDKVFYNGIECPIPNVYPASEEQDSGNQKRKFFDHKTYNNYLFWCTQGNNQIKKLLSDEIWISKMQIGITKHVEEGEDNDKSFYKQEFLQLKKSFIYAFYITLSGESELSSDIIQLGGQRSVFRMEVESIEENSDIQEKYQTAAQFLTQSDRLLILSPTYVDNLKELSALCNFMWSDSIVFRNIQTTNASNFYGKPIKSSSKYHFLKPGSVLYFKQGKRKEVEKLLMDYTYLRLSGYNIYI
Protein #4 279 residues (100% resolved)

MTTRMYVINTLSNMHVGSGEVNYGVIDNLIQRDSVTNLPNINSSGLKGAIREYFKENEDLVRELFGSAPRDEKTLPGKVRFFEANLLSMPVRSDKVPFLMAISDEVLQELITKMKFFNCEEATQYISHLSTLLDNIKTQAQGTDFAYVFDPLLQGAIIEEVSIRATCPSHIPLQPSLKKLLGDRLVILSHKYFSILSDDNHLPVLSRNNLENGQSANLWYEQVLPRYSRLYFMLMDGNAQSEYLKKFRDTLCTPSTIIQIGANASIGYGYCQISELSPF

MTTRMYVINTLSNMHVGSGEVNYGVIDNLIQRDSVTNLPNINSSGLKGAIREYFKENEDLVRELFGSAPRDEKTLPGKVRFFEANLLSMPVRSDKVPFLMAISDEVLQELITKMKFFNCEEATQYISHLSTLLDNIKTQAQGTDFAYVFDPLLQGAIIEEVSIRATCPSHIPLQPSLKKLLGDRLVILSHKYFSILSDDNHLPVLSRNNLENGQSANLWYEQVLPRYSRLYFMLMDGNAQSEYLKKFRDTLCTPSTIIQIGANASIGYGYCQISELSPF
Protein #5 136 residues (100% resolved)

MKISKKQIEYAIEALRANNIITNDNQYPKVFKGYISSFGAAVIQSGLIPAIIFFENEDNDANADRHKIIGVLKDIINAMRQQYTVTDATILVSSQIPANYSMAQYIIEHGNTDQLLKEITEAAVAMKLALRMYKSE

MKISKKQIEYAIEALRANNIITNDNQYPKVFKGYISSFGAAVIQSGLIPAIIFFENEDNDANADRHKIIGVLKDIINAMRQQYTVTDATILVSSQIPANYSMAQYIIEHGNTDQLLKEITEAAVAMKLALRMYKSE
Protein #6 314 residues (100% resolved)

MPKNYTLQNASNLGWLFYKDYYRQEPNVDFISTQGKESDTTADFFRKTNQRITAYQLNSESPLVAAFNNHFGTPLQLKTIYPGLITGSGLPHQTGSKGEFKLGFQFDYTTGLPYIPGSSIKGTLRSMFPFSLKDKGSTKRILPEYRKERMEYIRDLIIEVTNINEISDTEIQALEYAIFTNSTPSGKTIEFSLEEKDVFYDAFVADSKDGVMLSDDYITPHGENPLKDPKPILFLKIRPDVTINFYFKLCTTHLYKEKVCSSKQIEEIKKQNDFSSSDYKMITAHQKRNLFEKILLCIGIGAKTNIGYGQLKKL

MPKNYTLQNASNLGWLFYKDYYRQEPNVDFISTQGKESDTTADFFRKTNQRITAYQLNSESPLVAAFNNHFGTPLQLKTIYPGLITGSGLPHQTGSKGEFKLGFQFDYTTGLPYIPGSSIKGTLRSMFPFSLKDKGSTKRILPEYRKERMEYIRDLIIEVTNINEISDTEIQALEYAIFTNSTPSGKTIEFSLEEKDVFYDAFVADSKDGVMLSDDYITPHGENPLKDPKPILFLKIRPDVTINFYFKLCTTHLYKEKVCSSKQIEEIKKQNDFSSSDYKMITAHQKRNLFEKILLCIGIGAKTNIGYGQLKKL
RNA #7 49 bases

AUUAAGACAUUCGUGAGUGAUUUAUUUCCAUGAAGUGGCGUCCCUUGUG

AUUAAGACAUUCGUGAGUGAUUUAUUUCCAUGAAGUGGCGUCCCUUGUG
Non polymer #8 MN

InChI=1S/Mn/q+2

[Mn+2]
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Reference