2025-11-15_00000124|ligand|9J74

Cryo-EM structure of URAT1 in complex with lesinurad; Electron microscopy 3.68Å
Protein #1 553 residues (85% resolved)

MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQSMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLLMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCWFAFGFTFFGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDIAGGSVLKSARL

MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQSMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLLMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCWFAFGFTFFGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDIAGGSVLKSARL
Non polymer #2 A1AIL

InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)

c1ccc2c(c1)c(ccc2n3c(nnc3Br)SCC(=O)O)C4CC4
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Reference