2025-11-08_00000313|medium|9VGK

Ancestral L-tryptophan synthase beta-subunit 1 complex with Trp-PLP; X-ray diffraction 2.20Å
Protein #1 397 residues (98% resolved)

MKTYNVDENGYYGEFGGAYIPEILHKCVEDLQNNYLKILESPDFQKEYDQLLRDYVGRPSPLYLAKRLSEKYGCKIYLKREDLNHTGAHAINNTIGQILLARRMGKTRIIAETGAGQHGVATATVCALMNMECIVYMGKTDVERQHVNVQKMEMLGATVVPVTSGNMTLKDATNEAIRDWCCHPSDTYYIIGSTVGPHPYPDMVARLQSVISKEIKKQLQEKEGRDYPDYLIACVGGGSNAAGTIYHYIDDERVKIVLAEAGGKGIDSGMTAATIHLGKMGIIHGSKTLVMQNEDGQIEEPYSISAGLDYPGIGPMHANLAKQKRAQVLAINDDEALNAAFELTRLEGIIPALESAHALAALEKVKFKPEDVVVLTLSGRGDKDMETYLKYKKNSNE

MKTYNVDENGYYGEFGGAYIPEILHKCVEDLQNNYLKILESPDFQKEYDQLLRDYVGRPSPLYLAKRLSEKYGCKIYLKREDLNHTGAHAINNTIGQILLARRMGKTRIIAETGAGQHGVATATVCALMNMECIVYMGKTDVERQHVNVQKMEMLGATVVPVTSGNMTLKDATNEAIRDWCCHPSDTYYIIGSTVGPHPYPDMVARLQSVISKEIKKQLQEKEGRDYPDYLIACVGGGSNAAGTIYHYIDDERVKIVLAEAGGKGIDSGMTAATIHLGKMGIIHGSKTLVMQNEDGQIEEPYSISAGLDYPGIGPMHANLAKQKRAQVLAINDDEALNAAFELTRLEGIIPALESAHALAALEKVKFKPEDVVVLTLSGRGDKDMETYLKYKKNSNE
Non polymer #2 VB4

InChI=1S/C19H20N3O7P/c1-11-18(23)15(13(8-20-11)10-29-30(26,27)28)9-22-17(19(24)25)6-12-7-21-16-5-3-2-4-14(12)16/h2-5,7-9,17,21,23H,6,10H2,1H3,(H,24,25)(H2,26,27,28)/b22-9+/t17-/m1/s1

Cc1c(c(c(cn1)COP(=O)(O)O)/C=N/[C@H](Cc2c[nH]c3c2cccc3)C(=O)O)O
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Reference