2025-11-08_00000153|hard|9KJX

Cryo-EM structure of the Retron-Eco7 complex (state 1); Electron microscopy 2.76Å
Protein #1 322 residues (96% resolved)

MGHHHHHHGGGSSVIRGLAAVLRQSDSDISAFLVTAPRKYKVYKIPKRTTGFRVIAQPAKGLKDIQRAFVQLYSLPVHDASMAYMKGKGIRDNAAAHAGNQYLLKADLEDFFNSITPAIFWRCIEMSSAQTPQFEPQDKLFIEKILFWQPIKRRKTKLILSVGAPSSPVISNFCMYEFDNRIHAACKKVEITYTRYADDLTFSSNIPDVLKAVPSTLEVLLKDLFGSALRLNHSKTVFSSKAHNRHVTGITINNEETLSLGRDRKRFIKHLINQYKYGLLDNEDKAYLIGLLAFASHIEPSFITRMNEKYSLELMERLRGQR

MGHHHHHHGGGSSVIRGLAAVLRQSDSDISAFLVTAPRKYKVYKIPKRTTGFRVIAQPAKGLKDIQRAFVQLYSLPVHDASMAYMKGKGIRDNAAAHAGNQYLLKADLEDFFNSITPAIFWRCIEMSSAQTPQFEPQDKLFIEKILFWQPIKRRKTKLILSVGAPSSPVISNFCMYEFDNRIHAACKKVEITYTRYADDLTFSSNIPDVLKAVPSTLEVLLKDLFGSALRLNHSKTVFSSKAHNRHVTGITINNEETLSLGRDRKRFIKHLINQYKYGLLDNEDKAYLIGLLAFASHIEPSFITRMNEKYSLELMERLRGQR
Protein #2 550 residues (97% resolved)

MTKQYERKAKGGNLLSAFELYQRNSDKAPGLGEMLVGEWFEMCRDYIQDGHVDESGIFRPDNAFYLRRLTLKDFRRFSLLEIKLEEDLTVIIGNNGKGKTSILYAIAKTLSWFVANILKEGGSGQRLSEMTDIKNDAEDRYSDVSSTFFFGKGLKSVPIRLSRSALGTAERRDSEVKPAKDLADIWRVINEVNTINLPTFALYNVERSQPFNRNIKDNTGRREERFDAYSQTLGGAGRFDHFVEWYIYLHKRTVSDISSSIKELEQQVNDLQRTVDGGMVSVKSLLEQMKFKLSEAIERNDAAVSSRVLTESVQKSIVEKAICSVVPSISNIWVEMITGSDLVKVTNDGHDVTIDQLSDGQRVFLSLVADLARRMVMLNPLLENPLEGRGIVLIDEIELHLHPKWQQEVILNLRSAFPNIQFIITTHSPIVLSTIEKRCIREFEPNDDGDQSFLDSPDMQTKGSENAQILEQVMNVHSTPPGIAESHWLGNFELLLLDNSGELDNHSQVLYDQIKAHFGIDSIELKKADSLIRINKMKNKLNKIRAEKGK

MTKQYERKAKGGNLLSAFELYQRNSDKAPGLGEMLVGEWFEMCRDYIQDGHVDESGIFRPDNAFYLRRLTLKDFRRFSLLEIKLEEDLTVIIGNNGKGKTSILYAIAKTLSWFVANILKEGGSGQRLSEMTDIKNDAEDRYSDVSSTFFFGKGLKSVPIRLSRSALGTAERRDSEVKPAKDLADIWRVINEVNTINLPTFALYNVERSQPFNRNIKDNTGRREERFDAYSQTLGGAGRFDHFVEWYIYLHKRTVSDISSSIKELEQQVNDLQRTVDGGMVSVKSLLEQMKFKLSEAIERNDAAVSSRVLTESVQKSIVEKAICSVVPSISNIWVEMITGSDLVKVTNDGHDVTIDQLSDGQRVFLSLVADLARRMVMLNPLLENPLEGRGIVLIDEIELHLHPKWQQEVILNLRSAFPNIQFIITTHSPIVLSTIEKRCIREFEPNDDGDQSFLDSPDMQTKGSENAQILEQVMNVHSTPPGIAESHWLGNFELLLLDNSGELDNHSQVLYDQIKAHFGIDSIELKKADSLIRINKMKNKLNKIRAEKGK
Protein #3 266 residues (79% resolved)

MRELARLERPEILDQYIAGQNDWMEIDQSAVWPKLTEMQGGFCAYCECRLNRCHIEHFRPRGKFPALTFIWNNLFGSCGDSRKSGGWSRCGIYKDNGAGAYNADDLIKPDEENPDDYLLFLTTGEVVPAIGLTGRALKKAQETIRVFNLNGDIKLFGSRRTAVQAIMPNVEYLYTLLEEFDEDDWNEMLRDELEKIESDEYKTALKHAWTFNQEFAGGGSGGGSSSGLVPRGSHMASWSHPQFEKGGGSGGGSGGSAWSHPQFEKN

MRELARLERPEILDQYIAGQNDWMEIDQSAVWPKLTEMQGGFCAYCECRLNRCHIEHFRPRGKFPALTFIWNNLFGSCGDSRKSGGWSRCGIYKDNGAGAYNADDLIKPDEENPDDYLLFLTTGEVVPAIGLTGRALKKAQETIRVFNLNGDIKLFGSRRTAVQAIMPNVEYLYTLLEEFDEDDWNEMLRDELEKIESDEYKTALKHAWTFNQEFAGGGSGGGSSSGLVPRGSHMASWSHPQFEKGGGSGGGSGGSAWSHPQFEKN
RNA #4 146 bases

GGACUCUUUAGCGUUGGACGGUUACGUCUAGUCGGGUGAUUAGCCAGACUCUAACUUAUUGAACGUAUUAAGGGUUGCGAAAGUGUCGCAACCCGAGAUCGUUCCUCUCUCGGGUUGCGACACUUUCGCUUCCUCAAGUAAAGAGU

GGACUCUUUAGCGUUGGACGGUUACGUCUAGUCGGGUGAUUAGCCAGACUCUAACUUAUUGAACGUAUUAAGGGUUGCGAAAGUGUCGCAACCCGAGAUCGUUCCUCUCUCGGGUUGCGACACUUUCGCUUCCUCAAGUAAAGAGU
DNA #5 77 bases

(DT)(DT)(DG)(DA)(DG)(DG)(DA)(DA)(DG)(DC)(DG)(DA)(DA)(DA)(DG)(DT)(DG)(DT)(DC)(DG)(DC)(DA)(DA)(DC)(DC)(DC)(DG)(DA)(DG)(DA)(DG)(DA)(DG)(DG)(DA)(DA)(DC)(DG)(DA)(DT)(DC)(DT)(DC)(DG)(DG)(DG)(DT)(DT)(DG)(DC)(DG)(DA)(DC)(DA)(DC)(DT)(DT)(DT)(DC)(DG)(DC)(DA)(DA)(DC)(DC)(DC)(DT)(DT)(DA)(DA)(DT)(DA)(DC)(DG)(DT)(DT)(DC)

TTGAGGAAGCGAAAGTGTCGCAACCCGAGAGAGGAACGATCTCGGGTTGCGACACTTTCGCAACCCTTAATACGTTC
Non polymer #6 ADP

InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
Non polymer #7 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #8 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference