2025-11-01_00000306|ligand|9ND5

JAK2 pseudokinase domain in complex with diaminotriazole covalent inhibitor; X-ray diffraction 2.40Å
Protein #1 280 residues (98% resolved)

VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDHRPSFRAIIRDLNSLFHHHHHH

VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDHRPSFRAIIRDLNSLFHHHHHH
Non polymer #2 A1BXA

InChI=1S/C15H15FN6O6S2/c16-30(26,27)28-11-3-1-2-9(8-11)13(23)22-14(17)20-15(21-22)19-10-4-6-12(7-5-10)29(18,24)25/h1-8,26-27H,(H2,18,24,25)(H3,17,19,20,21)

c1cc(cc(c1)OS(O)(O)F)C(=O)n2c(nc(n2)Nc3ccc(cc3)S(=O)(=O)N)N
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