2025-11-01_00000245|ligand|9KC2

Cryo-EM structure of ZSQ07-bound alpha-synuclein fibril polymorph 6A6B; Electron microscopy 2.90Å
Protein #1 140 residues (44% resolved)

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Non polymer #2 A1EFK

InChI=1S/C22H21N2OS/c1-23-20-10-4-5-11-21(20)26-22(23)12-6-7-17-13-14-24(15-16-25)19-9-3-2-8-18(17)19/h2-14,25H,15-16H2,1H3/b12-6+,17-7+

C[N]1=C(Sc2c1cccc2)/C=C/C=C/3\C=CN(c4c3cccc4)CCO
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Reference