2025-10-25_00000358|ligand|9W76

sarbecovirus Rc-o319 S-trimer in a locked-2 conformation; Electron microscopy 2.30Å
Protein #1 1254 residues (86% resolved)

MFILVLLNVLSVYGCVNITYGSHHLYVSSRTRGVYYPDDAFRSSTNVLHEGFFLPFDSNVTWYSFWNQKYSVATSPFGDGVYFSTIDKSNVVRGWVFGTTLDNDTQSVLLYNDGTHVRVEVCTFHFCPTPVFSASSPHLYSSAFNCTLNYTLASVRADFTEVDGSFKTIREFVFKLQDGSLNVYYASTSYVLAIGATSQLPSGVTPLVPLWKIPIGLNITNFKTLVYLRSDNTPLQAAYVVGHLKRRTMMFKYDENGTIVDAIDCALDPLSETKCTLRSFIVEKGIYQTSNFRVQPQDTVVRFPNITNLCPFSEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFQCYGVSSTKLNDLCFTNVYADSFVVRGDEVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNSRNQDASTSGNFNYYYRIWRSEKLRPFERDIAHYDYQVGTQFKSSLKNYGFYSSAGDSHQPYRVVVLSFELLNAPATVCGPKQSTELIKNKCVNFNFNGLTGTGVLTDSNKKFQSFQQFGRDVSDFTDSVKDPKTLEVLDITPCSYGGVSVITPGTNASTQVAVLYQDVNCTDVPTAIHAEQLTPSWRVYSTGTNMFQTQAGCLIGAEHVNNSYDCDIPIGAGICATYHTPSMLRSANNNKRIVAYVMSLGAENSVAYSNNTIAIPTNFTISVTTEVMPVSMTKTSVDCTMYICGDSVECSTLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPDIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFVKQYGDCLGDIQARDLICAQKFNGLTVLPPLLTDEMIAAYTAALISGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQESLTSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDIISRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYIPSQERNFTTAPAICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDNTFVSGTCDVVIGIVNNTVYDPLQPELESFKDELDKYFKNHTSPDIDLGDISGINASVVDIQKEIDILKDVAKNLNESLINLQELGKYEQYIKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA

MFILVLLNVLSVYGCVNITYGSHHLYVSSRTRGVYYPDDAFRSSTNVLHEGFFLPFDSNVTWYSFWNQKYSVATSPFGDGVYFSTIDKSNVVRGWVFGTTLDNDTQSVLLYNDGTHVRVEVCTFHFCPTPVFSASSPHLYSSAFNCTLNYTLASVRADFTEVDGSFKTIREFVFKLQDGSLNVYYASTSYVLAIGATSQLPSGVTPLVPLWKIPIGLNITNFKTLVYLRSDNTPLQAAYVVGHLKRRTMMFKYDENGTIVDAIDCALDPLSETKCTLRSFIVEKGIYQTSNFRVQPQDTVVRFPNITNLCPFSEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFQCYGVSSTKLNDLCFTNVYADSFVVRGDEVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNSRNQDASTSGNFNYYYRIWRSEKLRPFERDIAHYDYQVGTQFKSSLKNYGFYSSAGDSHQPYRVVVLSFELLNAPATVCGPKQSTELIKNKCVNFNFNGLTGTGVLTDSNKKFQSFQQFGRDVSDFTDSVKDPKTLEVLDITPCSYGGVSVITPGTNASTQVAVLYQDVNCTDVPTAIHAEQLTPSWRVYSTGTNMFQTQAGCLIGAEHVNNSYDCDIPIGAGICATYHTPSMLRSANNNKRIVAYVMSLGAENSVAYSNNTIAIPTNFTISVTTEVMPVSMTKTSVDCTMYICGDSVECSTLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPDIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFVKQYGDCLGDIQARDLICAQKFNGLTVLPPLLTDEMIAAYTAALISGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQESLTSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDIISRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYIPSQERNFTTAPAICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDNTFVSGTCDVVIGIVNNTVYDPLQPELESFKDELDKYFKNHTSPDIDLGDISGINASVVDIQKEIDILKDVAKNLNESLINLQELGKYEQYIKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA
Non polymer #2 BLA

InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,34H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-,29-15-

Cc1c(c([nH]c1\C=C/2\C(=C(C(=O)N2)C=C)C)\C=C/3\C(=C(C(=N3)\C=C/4\C(=C(C(=O)N4)C)C=C)C)CCC(=O)O)CCC(=O)O
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference