2025-10-25_00000090|ligand|9H30

VHL:ElonginC:ElonginB-PROTAC4 complex; X-ray diffraction 2.50Å
Protein #1 197 residues (73% resolved)

MNTIHHHHHHNTSGSGGGGGRLVPRGSMSENLYFQGSMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

MNTIHHHHHHNTSGSGGGGGRLVPRGSMSENLYFQGSMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Protein #2 97 residues (91% resolved)

MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
Protein #3 104 residues (98% resolved)

MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMK

MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMK
Non polymer #4 A1ISE

InChI=1S/C66H82ClN9O13S/c1-38-14-13-16-52(86-10)66(84)33-51(87-63(83)71-66)39(2)59-65(7,89-59)53(32-55(79)74(8)48-29-43(28-38)30-50(85-9)56(48)67)88-62(82)45-24-18-41(19-25-45)26-27-75-35-46(72-73-75)15-11-12-17-54(78)70-58(64(4,5)6)61(81)76-36-47(77)31-49(76)60(80)68-34-42-20-22-44(23-21-42)57-40(3)69-37-90-57/h13-14,16,18-25,29-30,35,37,39,47,49,51-53,58-59,77,84H,11-12,15,17,26-28,31-34,36H2,1-10H3,(H,68,80)(H,70,78)(H,71,83)/b16-13+,38-14+/t39-,47-,49+,51+,52-,53+,58+,59+,65+,66+/m1/s1

Cc1c(scn1)c2ccc(cc2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](C(C)(C)C)NC(=O)CCCCc4cn(nn4)CCc5ccc(cc5)C(=O)O[C@H]6CC(=O)N(c7cc(cc(c7Cl)OC)C/C(=C/C=C/[C@H]([C@]8(C[C@@H]([C@H]([C@H]9C6(O9)C)C)OC(=O)N8)O)OC)/C)C)O
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