2025-10-18_00000234|ligand|9K0I

Crystal structure of FGFR4 kinase domain with 32a; X-ray diffraction 2.24Å
Protein #1 311 residues (96% resolved)

GPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE

GPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE
Non polymer #2 A1EEW

InChI=1S/C36H39Cl2FN8O3/c1-21(33-28(37)19-41-20-29(33)38)50-26-4-5-31-27(17-26)35(45-44-31)43-34-30(39)15-25(16-32(34)42-36(48)23(18-40)14-22-2-3-22)46-8-6-24(7-9-46)47-10-12-49-13-11-47/h4-5,15-17,19-24H,2-3,6-14H2,1H3,(H,42,48)(H2,43,44,45)/t21-,23+/m1/s1

C[C@H](c1c(cncc1Cl)Cl)Oc2ccc3c(c2)c(n[nH]3)Nc4c(cc(cc4F)N5CCC(CC5)N6CCOCC6)NC(=O)[C@@H](CC7CC7)C#N
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