2025-09-20_00000128|ligand|9KL4

Crystal structure of EGFR complexed with N-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide; X-ray diffraction 2.32Å
Protein #1 330 residues (95% resolved)

GSMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG

GSMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
Non polymer #2 A1L53

InChI=1S/C29H24N8O/c1-2-22-23(19-11-18-5-3-4-6-21(18)33-14-19)24-25(30)34-17-35-26(24)37(22)29-9-7-28(15-29,8-10-29)36-27(38)20-12-31-16-32-13-20/h1,3-6,11-14,16-17H,7-10,15H2,(H,36,38)(H2,30,34,35)/t28-,29+

C#Cc1c(c2c(ncnc2n1C34CCC(C3)(CC4)NC(=O)c5cncnc5)N)c6cc7ccccc7nc6
Non polymer #3 CL

InChI=1S/ClH/h1H/p-1

[Cl-]
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