2025-09-20_00000003
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ligand
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8YQE
CDK2 and small molecular inhibitor L56;
X-ray diffraction 1.94Å
Protein #1
303 residues (95% resolved)
Raw Sequence ...
GPLGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Canonical Sequence ...
GPLGSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Non polymer #2
A1D60
InChI=1S/C23H29F2N5O5S/c1-2-36(33,34)30-9-5-15(6-10-30)27-23(32)21-18(13-26-29-21)28-22(31)19-17(24)4-3-16(20(19)25)14-7-11-35-12-8-14/h3-4,13-15H,2,5-12H2,1H3,(H,26,29)(H,27,32)(H,28,31)
InChI=1S/C23H29F2N5O5S/c1-2-36(33,34)30-9-5-15(6-10-30)27-23(32)21-18(13-26-29-21)28-22(31)19-17(24)4-3-16(20(19)25)14-7-11-35-12-8-14/h3-4,13-15H,2,5-12H2,1H3,(H,26,29)(H,27,32)(H,28,31)
SMILES: CCS(=O)(=O)N1CCC(CC1)NC(=O)c2c(cn[nH]2)NC(=O)c3c(ccc(c3F)C4CCOCC4)F
CCS(=O)(=O)N1CCC(CC1)NC(=O)c2c(cn[nH]2)NC(=O)c3c(ccc(c3F)C4CCOCC4)F
Biounit #1
monomer
Download coordinates
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Model
Reference
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