2025-09-13_00000193|ligand|9RLS

PARP10 catalytic domain in complex with OUL499; X-ray diffraction 2.75Å

Protein #1 191 residues (99% resolved)

Raw Sequence ...

SMNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHV

Canonical Sequence ...

SMNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHV

Non polymer #2 A1JHC

InChI=1S/C15H11ClN2O3/c16-10-3-1-2-9(6-10)8-21-11-4-5-12-13(7-11)15(20)18-17-14(12)19/h1-7H,8H2,(H,17,19)(H,18,20)

SMILES: c1cc(cc(c1)Cl)COc2ccc3c(c2)C(=O)NNC3=O

c1cc(cc(c1)Cl)COc2ccc3c(c2)C(=O)NNC3=O

Reference