2025-09-13_00000181|hard|9R19

Crystal structure of human ACE2 in complex with VHH B07 and VHH B10; X-ray diffraction 2.69Å

Protein #1 604 residues (99% resolved)

Raw Sequence ...

STIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADGSGLVPR

Canonical Sequence ...

Protein #2 153 residues (82% resolved)

Raw Sequence ...

MAQVQLVESGGGLVQAGDSLRLSCAASGRTFSSYAMGWFRQALGKEREFVAVISGSGTSTYYTDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCARAKGFSTIYNQDEGRYDYWGQGTQVTVSSAAAEQKLISEEDLNGAAHHHHHHGS

Canonical Sequence ...

MAQVQLVESGGGLVQAGDSLRLSCAASGRTFSSYAMGWFRQALGKEREFVAVISGSGTSTYYTDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCARAKGFSTIYNQDEGRYDYWGQGTQVTVSSAAAEQKLISEEDLNGAAHHHHHHGS

Protein #3 143 residues (83% resolved)

Raw Sequence ...

MAEVQLQASGGGLVQAGGSLRLSCAASRSTFSTNTIGWYRQAPGKQRELVASISTSGNTYYPDSVKGRFAISRDNAENTVYLQMNSLKPEDTAVYYCNTPSRRISNFWGQGTQVTVSSAAAEQKLISEEDLNGAAHHHHHHGS

Canonical Sequence ...

MAEVQLQASGGGLVQAGGSLRLSCAASRSTFSTNTIGWYRQAPGKQRELVASISTSGNTYYPDSVKGRFAISRDNAENTVYLQMNSLKPEDTAVYYCNTPSRRISNFWGQGTQVTVSSAAAEQKLISEEDLNGAAHHHHHHGS

Non polymer #4 CL

InChI=1S/ClH/h1H/p-1

SMILES: [Cl-]

[Cl-]

Non polymer #5 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

Biounit #1 hetero-1-1-1-mer

Biounit #2 hetero-1-1-1-mer

Biounit #3 hetero-1-1-1-mer

Reference