2025-09-13_00000144|hard|9NHC

Cryo-EM structure of SIWI-piRNA-target(49-nt)-GTSF1-Maelstrom complex; Electron microscopy 3.60Å
Protein #1 899 residues (84% resolved)

MSEPRGRGRARGRAGRGGDGGGPAPRRPGEQAGPSQQSMPPGPRPQPPSGWGPQSSVPPVRAGVPTPTAQAGRASHRVTPTTHEHPGDIDVQQRMQKLELGPHSSGGGDASSVVGRGSRRGGGRVLPETISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEEDSTGVRKALMRVHSKTLGGYLFDGTVLYTVNRLHPDPMELYSDRKTDNERMRILIKLTCEVSPGDYHYIQIFNIIIRKCFNLLKLQLMGRDYFDPEAKIDIPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATKGNNYKKIFLEDVVGKIVMTDYNKRTYRVDDVAWNVSPKSTFKMRDENITYIEYYYKKYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRANFKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKELVKIKGRQLPPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQLNSWVVITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEEVIARKNPALILCVLARNYADRYEAIKKKCTVDRAVPTQVVCARNMSSKSAMSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAFVATLDKQMTQYYSIVNAHTSGEELSSHMGFNIASAVKKFREKNGTYPARIFIYRDGVGDGQIPYVHSHEVAEIKKKLAEIYAGVEIKLAFIIVSKRINTRIFVQRGRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTGLNPDRIQRLTYKLTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHYSLNETLYFL

MSEPRGRGRARGRAGRGGDGGGPAPRRPGEQAGPSQQSMPPGPRPQPPSGWGPQSSVPPVRAGVPTPTAQAGRASHRVTPTTHEHPGDIDVQQRMQKLELGPHSSGGGDASSVVGRGSRRGGGRVLPETISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEEDSTGVRKALMRVHSKTLGGYLFDGTVLYTVNRLHPDPMELYSDRKTDNERMRILIKLTCEVSPGDYHYIQIFNIIIRKCFNLLKLQLMGRDYFDPEAKIDIPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATKGNNYKKIFLEDVVGKIVMTDYNKRTYRVDDVAWNVSPKSTFKMRDENITYIEYYYKKYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRANFKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKELVKIKGRQLPPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQLNSWVVITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEEVIARKNPALILCVLARNYADRYEAIKKKCTVDRAVPTQVVCARNMSSKSAMSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAFVATLDKQMTQYYSIVNAHTSGEELSSHMGFNIASAVKKFREKNGTYPARIFIYRDGVGDGQIPYVHSHEVAEIKKKLAEIYAGVEIKLAFIIVSKRINTRIFVQRGRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTGLNPDRIQRLTYKLTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHYSLNETLYFL
RNA #2 25 bases

UGGAGUGUGACAAUGGUGUUUGAU(A2M)

UGGAGUGUGACAAUGGUGUUUGAUA
RNA #3 49 bases

AAAAAAAUAUCAAACACCAUUGUCACACUCCAAAAAAAACCCCAAAACC

AAAAAAAUAUCAAACACCAUUGUCACACUCCAAAAAAAACCCCAAAACC
Protein #4 149 residues (100% resolved)

MEVTIANPKPNQMITCPYEKAHIVEHYRMHIHLQKCRKQHPACNKVQCPFDATHVVNDVELDFHVTVCPKRHMLDTQLYITDDEYRPTVEVHATPVLPSDENWDDETSTSYIPDPSKKGAHIITKAKGLTRSERQSLRKELIKTYRPLE

MEVTIANPKPNQMITCPYEKAHIVEHYRMHIHLQKCRKQHPACNKVQCPFDATHVVNDVELDFHVTVCPKRHMLDTQLYITDDEYRPTVEVHATPVLPSDENWDDETSTSYIPDPSKKGAHIITKAKGLTRSERQSLRKELIKTYRPLE
Protein #5 440 residues (58% resolved)

MPKKKTPQNPFFFFMMDYRKEQAEIGIKYANTKELAEAAGPVWQNLRPTLKAKYEEKAKNEKEKNKQTGTKFTSTGIPIKVIEQQQREMKNAEDNEKKDIQNIVKLKVFDQSIKTEDFYVIDVNSYCKANGDYLIGEFTVTQFSLQDGVKNSYHETIIPSCVPVGYMFDVKLGAEEFGLEMPGTDDAGPNYIQILANIIDYLKQKDRTVQVLPPMFTLPEKVDAVQNFISQMCNCATEDDSLFRIYKLDTFFFTLINAISSHHDEGFPKESLALTQLTKDLFDYTPGIACERHESLDRSNVCTTSRVKRWVFTILDRCCPLLGIPLQPGKHLPFDYDINGILIFKEERKTRAAPSVPRTATASSNSSFINDSLNESFQSLNVTGETAASGSAPGRRVHKPLRMPRTDYSQRIQQAPELTEANFPTLTGHGRGRGLTRSNN

MPKKKTPQNPFFFFMMDYRKEQAEIGIKYANTKELAEAAGPVWQNLRPTLKAKYEEKAKNEKEKNKQTGTKFTSTGIPIKVIEQQQREMKNAEDNEKKDIQNIVKLKVFDQSIKTEDFYVIDVNSYCKANGDYLIGEFTVTQFSLQDGVKNSYHETIIPSCVPVGYMFDVKLGAEEFGLEMPGTDDAGPNYIQILANIIDYLKQKDRTVQVLPPMFTLPEKVDAVQNFISQMCNCATEDDSLFRIYKLDTFFFTLINAISSHHDEGFPKESLALTQLTKDLFDYTPGIACERHESLDRSNVCTTSRVKRWVFTILDRCCPLLGIPLQPGKHLPFDYDINGILIFKEERKTRAAPSVPRTATASSNSSFINDSLNESFQSLNVTGETAASGSAPGRRVHKPLRMPRTDYSQRIQQAPELTEANFPTLTGHGRGRGLTRSNN
Non polymer #6 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #7 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference