2025-09-06_00000095|hard|9JG3

Structure of Cas12p-TrxA-guide RNA-target DNA complex(33-bp dsDNA); Electron microscopy 3.20Å
Protein #1 741 residues (78% resolved)

MGSSHHHHHHSSGLVPRGSMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGHSSLEVLFQGPMKTIKIKIKLTTDQVQLCDRYLEELTWLWNLTLSNQLHNHCVTWYAWAAKLSADLDKATEKLDKLKPEQQQLVKDYYRTKDKPRLTKKEQELVAKFDIFARWSSFSLDGIIPVPLRLGNSGYEGLSCQIATGGNYWKRDENINIPINTKKGIIHVKGYKLVKGDKLWQRIEIVPHKYRTFPGGKFEGRELTTLEKLDNVNGLNTLRAFQNLPDLQVSSHYIGGLLAFFKESWSAFLDPKRMNSRKPKFKKDSDKITTLSNNQCAPNRIDVNKNIVTVTGFSPITIIDKNWVKRLNLSQVLPRTYMLTQNPSGYYINIVIAHPLHEEKIALVKKLPKVKKEFGEDSQEYEDIKSKIKFLEQQIKESSIVKGKDLSVGIDPGVQAVVSTDHGALFLPNLTRERVSIHIEELQSRLDNAELINDKKWKSLGNKTPRIKTKNETKLQEKISRLHERGANSSNAFNHKLSTRLSRTYEHIAWEDTQINNLLKQVEPKALPEGVGYAHNGASAKRGLNWIMRQRCLSDLKAKTKQKTENRGGNFHEPPANYSSQTCHCCGQKGERRSQHEFVCKNSDCKLFDIPQQADTNAARNHKQNGGFELGEVKYHNVKLVYQKPK

MGSSHHHHHHSSGLVPRGSMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGHSSLEVLFQGPMKTIKIKIKLTTDQVQLCDRYLEELTWLWNLTLSNQLHNHCVTWYAWAAKLSADLDKATEKLDKLKPEQQQLVKDYYRTKDKPRLTKKEQELVAKFDIFARWSSFSLDGIIPVPLRLGNSGYEGLSCQIATGGNYWKRDENINIPINTKKGIIHVKGYKLVKGDKLWQRIEIVPHKYRTFPGGKFEGRELTTLEKLDNVNGLNTLRAFQNLPDLQVSSHYIGGLLAFFKESWSAFLDPKRMNSRKPKFKKDSDKITTLSNNQCAPNRIDVNKNIVTVTGFSPITIIDKNWVKRLNLSQVLPRTYMLTQNPSGYYINIVIAHPLHEEKIALVKKLPKVKKEFGEDSQEYEDIKSKIKFLEQQIKESSIVKGKDLSVGIDPGVQAVVSTDHGALFLPNLTRERVSIHIEELQSRLDNAELINDKKWKSLGNKTPRIKTKNETKLQEKISRLHERGANSSNAFNHKLSTRLSRTYEHIAWEDTQINNLLKQVEPKALPEGVGYAHNGASAKRGLNWIMRQRCLSDLKAKTKQKTENRGGNFHEPPANYSSQTCHCCGQKGERRSQHEFVCKNSDCKLFDIPQQADTNAARNHKQNGGFELGEVKYHNVKLVYQKPK
RNA #2 246 bases

AGAUUUAAGAAAAAACGCUUGACAAAGUAAUAAGAUUAGGCUAAUAUUAAAUUACCGCAGUUUGGGCGGGCAGCUAAUAAUAUUAGCUUAUGACUUCUAAGGCUUUUGCCUAAAAAGUAAGGGGGAAGGCGACAACCCCCAAAGACCAGCCGGAACUAUGGCUGGCAACUAUACCCUCUCUUUUGGAAACUUGCAACUAAGACUGGGGACUGAGGAUAGUUGAAACUGUCCUCUUCCUCUUUAGCG

AGAUUUAAGAAAAAACGCUUGACAAAGUAAUAAGAUUAGGCUAAUAUUAAAUUACCGCAGUUUGGGCGGGCAGCUAAUAAUAUUAGCUUAUGACUUCUAAGGCUUUUGCCUAAAAAGUAAGGGGGAAGGCGACAACCCCCAAAGACCAGCCGGAACUAUGGCUGGCAACUAUACCCUCUCUUUUGGAAACUUGCAACUAAGACUGGGGACUGAGGAUAGUUGAAACUGUCCUCUUCCUCUUUAGCG
DNA #3 33 bases

(DT)(DG)(DA)(DG)(DC)(DG)(DC)(DT)(DA)(DA)(DA)(DG)(DA)(DG)(DG)(DA)(DA)(DG)(DA)(DG)(DG)(DA)(DC)(DA)(DT)(DA)(DC)(DA)(DG)(DT)(DT)(DG)(DA)

TGAGCGCTAAAGAGGAAGAGGACATACAGTTGA
DNA #4 33 bases

(DT)(DC)(DA)(DA)(DC)(DT)(DG)(DT)(DA)(DT)(DG)(DT)(DC)(DC)(DT)(DC)(DT)(DT)(DC)(DC)(DT)(DC)(DT)(DT)(DT)(DA)(DG)(DC)(DG)(DC)(DT)(DC)(DA)

TCAACTGTATGTCCTCTTCCTCTTTAGCGCTCA
Protein #5 109 residues (96% resolved)

MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA

MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
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Reference