2025-09-06_00000094|hard|9JFS

Structure of Cas12p-TrxA-guide RNA-target DNA complex(29nt TS and 11nt NTS); Electron microscopy 2.67Å
Protein #1 741 residues (71% resolved)

MGSSHHHHHHSSGLVPRGSMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGHSSLEVLFQGPMKTIKIKIKLTTDQVQLCDRYLEELTWLWNLTLSNQLHNHCVTWYAWAAKLSADLDKATEKLDKLKPEQQQLVKDYYRTKDKPRLTKKEQELVAKFDIFARWSSFSLDGIIPVPLRLGNSGYEGLSCQIATGGNYWKRDENINIPINTKKGIIHVKGYKLVKGDKLWQRIEIVPHKYRTFPGGKFEGRELTTLEKLDNVNGLNTLRAFQNLPDLQVSSHYIGGLLAFFKESWSAFLDPKRMNSRKPKFKKDSDKITTLSNNQCAPNRIDVNKNIVTVTGFSPITIIDKNWVKRLNLSQVLPRTYMLTQNPSGYYINIVIAHPLHEEKIALVKKLPKVKKEFGEDSQEYEDIKSKIKFLEQQIKESSIVKGKDLSVGIDPGVQAVVSTDHGALFLPNLTRERVSIHIEELQSRLDNAELINDKKWKSLGNKTPRIKTKNETKLQEKISRLHERGANSSNAFNHKLSTRLSRTYEHIAWEDTQINNLLKQVEPKALPEGVGYAHNGASAKRGLNWIMRQRCLSDLKAKTKQKTENRGGNFHEPPANYSSQTCHCCGQKGERRSQHEFVCKNSDCKLFDIPQQADTNAARNHKQNGGFELGEVKYHNVKLVYQKPK

MGSSHHHHHHSSGLVPRGSMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGHSSLEVLFQGPMKTIKIKIKLTTDQVQLCDRYLEELTWLWNLTLSNQLHNHCVTWYAWAAKLSADLDKATEKLDKLKPEQQQLVKDYYRTKDKPRLTKKEQELVAKFDIFARWSSFSLDGIIPVPLRLGNSGYEGLSCQIATGGNYWKRDENINIPINTKKGIIHVKGYKLVKGDKLWQRIEIVPHKYRTFPGGKFEGRELTTLEKLDNVNGLNTLRAFQNLPDLQVSSHYIGGLLAFFKESWSAFLDPKRMNSRKPKFKKDSDKITTLSNNQCAPNRIDVNKNIVTVTGFSPITIIDKNWVKRLNLSQVLPRTYMLTQNPSGYYINIVIAHPLHEEKIALVKKLPKVKKEFGEDSQEYEDIKSKIKFLEQQIKESSIVKGKDLSVGIDPGVQAVVSTDHGALFLPNLTRERVSIHIEELQSRLDNAELINDKKWKSLGNKTPRIKTKNETKLQEKISRLHERGANSSNAFNHKLSTRLSRTYEHIAWEDTQINNLLKQVEPKALPEGVGYAHNGASAKRGLNWIMRQRCLSDLKAKTKQKTENRGGNFHEPPANYSSQTCHCCGQKGERRSQHEFVCKNSDCKLFDIPQQADTNAARNHKQNGGFELGEVKYHNVKLVYQKPK
RNA #2 246 bases

AGAUUUAAGAAAAAACGCUUGACAAAGUAAUAAGAUUAGGCUAAUAUUAAAUUACCGCAGUUUGGGCGGGCAGCUAAUAAUAUUAGCUUAUGACUUCUAAGGCUUUUGCCUAAAAAGUAAGGGGGAAGGCGACAACCCCCAAAGACCAGCCGGAACUAUGGCUGGCAACUAUACCCUCUCUUUUGGAAACUUGCAACUAAGACUGGGGACUGAGGAUAGUUGAAACUGUCCUCUUCCUCUUUAGCG

AGAUUUAAGAAAAAACGCUUGACAAAGUAAUAAGAUUAGGCUAAUAUUAAAUUACCGCAGUUUGGGCGGGCAGCUAAUAAUAUUAGCUUAUGACUUCUAAGGCUUUUGCCUAAAAAGUAAGGGGGAAGGCGACAACCCCCAAAGACCAGCCGGAACUAUGGCUGGCAACUAUACCCUCUCUUUUGGAAACUUGCAACUAAGACUGGGGACUGAGGAUAGUUGAAACUGUCCUCUUCCUCUUUAGCG
DNA #3 29 bases

(DC)(DG)(DC)(DT)(DA)(DA)(DA)(DG)(DA)(DG)(DG)(DA)(DA)(DG)(DA)(DG)(DG)(DA)(DC)(DA)(DT)(DA)(DC)(DA)(DG)(DT)(DT)(DG)(DA)

CGCTAAAGAGGAAGAGGACATACAGTTGA
DNA #4 11 bases

(DT)(DC)(DA)(DA)(DC)(DT)(DG)(DT)(DA)(DT)(DG)

TCAACTGTATG
Protein #5 109 residues (96% resolved)

MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA

MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
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Reference