2025-08-30_00000208
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ligand
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9JCU
TDI01 binding WT ROCK2 KD;
X-ray diffraction 3.02Å
Protein #1
391 residues (99% resolved)
Raw Sequence ...
QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYR
Canonical Sequence ...
QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYR
Non polymer #2
A1EBC
InChI=1S/C28H21F2N7O2/c1-36-22-11-18(3-2-17(22)10-23(36)27(38)37-14-28(29,30)15-37)25-34-21-8-9-39-24(21)26(35-25)33-20-6-4-16(5-7-20)19-12-31-32-13-19/h2-13H,14-15H2,1H3,(H,31,32)(H,33,34,35)
InChI=1S/C28H21F2N7O2/c1-36-22-11-18(3-2-17(22)10-23(36)27(38)37-14-28(29,30)15-37)25-34-21-8-9-39-24(21)26(35-25)33-20-6-4-16(5-7-20)19-12-31-32-13-19/h2-13H,14-15H2,1H3,(H,31,32)(H,33,34,35)
SMILES: Cn1c2cc(ccc2cc1C(=O)N3CC(C3)(F)F)c4nc5ccoc5c(n4)Nc6ccc(cc6)c7c[nH]nc7
Cn1c2cc(ccc2cc1C(=O)N3CC(C3)(F)F)c4nc5ccoc5c(n4)Nc6ccc(cc6)c7c[nH]nc7
Biounit #1
homo-dimer
Download coordinates
Biounit #2
homo-dimer
Download coordinates
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Model
Reference
100%