2025-08-23_00000003|ligand|8VMK

A crystal structure of heme-dependent tyrosine hydroxylase complexed with a substrate analog, 3-(4-hydroxyphenyl)propionic acid; X-ray diffraction 1.56Å
Protein #1 316 residues (96% resolved)

GHMNTGTGTVLTELPDHGRWDFGDFPYGLEPLTLPEPGSLEAADSGSVPAEFTLTCRHIAAIAAGGGPAERVQPADSSDRLYWFRWITGHQVTFILWQLLSRELARLPEEGPERDAALKAMTRYVRGYCAMLLYTGSMPRTVYGDVIRPSMFLQHPGFSGTWAPDHKPVQALFRGKKLPCVRDSADLAQAVHVYQVIHAGIAARMVPSGRSLLQEASVPSGVQHPDVLGVVYDNYFLTLRSRPSSRDVVAQLLRRLTAIALDVKDNALYPDGREAGSELPEELTRPEVTGHERDFLAILSEVAEEATGSPALASDR

GHMNTGTGTVLTELPDHGRWDFGDFPYGLEPLTLPEPGSLEAADSGSVPAEFTLTCRHIAAIAAGGGPAERVQPADSSDRLYWFRWITGHQVTFILWQLLSRELARLPEEGPERDAALKAMTRYVRGYCAMLLYTGSMPRTVYGDVIRPSMFLQHPGFSGTWAPDHKPVQALFRGKKLPCVRDSADLAQAVHVYQVIHAGIAARMVPSGRSLLQEASVPSGVQHPDVLGVVYDNYFLTLRSRPSSRDVVAQLLRRLTAIALDVKDNALYPDGREAGSELPEELTRPEVTGHERDFLAILSEVAEEATGSPALASDR
Non polymer #2 HEM

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
Non polymer #3 HPP

InChI=1S/C9H10O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5,10H,3,6H2,(H,11,12)

c1cc(ccc1CCC(=O)O)O
Non polymer #4 TRS

InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2/p+1

C(C(CO)(CO)[NH3+])O
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Reference