2025-08-16_00000203|ligand|9GET

Crystal structure of CREBBP bromodomain in complex with (R,E)-6-(5-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)pent-1-en-1-yl)-4-methyl-8-(morpholine-4-carbonyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one; X-ray diffraction 1.29Å
Protein #1 119 residues (100% resolved)

SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG

SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
Non polymer #2 A1IKM

InChI=1S/C30H38N4O4/c1-21-17-28(35)32-26-19-24(30(36)34-13-15-38-16-14-34)18-23(29(26)31-21)7-4-3-5-11-33-12-6-8-22-9-10-25(37-2)20-27(22)33/h4,7,9-10,18-21,31H,3,5-6,8,11-17H2,1-2H3,(H,32,35)/b7-4+/t21-/m1/s1

C[C@@H]1CC(=O)Nc2cc(cc(c2N1)/C=C/CCCN3CCCc4c3cc(cc4)OC)C(=O)N5CCOCC5
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Reference