2025-08-16_00000163|hard|9DCZ

Designed allosteric facilitated dissociation switch AS1 in complex state TH with methylated lysines, crystal #1; X-ray diffraction 2.90Å
Protein #1 263 residues (97% resolved)

MSGSM(MLY)EEI(MLY)RLAEEL(MLY)E(MLY)T(MLY)NEEI(MLY)RLAEEAAELAERSDDPEVLEVV(MLY)(MLY)ALEEAL(MLY)S(MLY)NEE(MLY)IELLLLVAVLVAEAGSVDAVEE(MLY)LEIALLAL(MLY)LAEES(MLY)DPRIIRGALRAAIAALRSDDPLAL(MLY)TV(MLY)EALERARAS(MLY)DERLIRAILAAAYAFALLAVAGASAERL(MLY)EAEAIV(MLY)ELIAAAE(MLY)GASPQELVLLVIEMMV(MLY)GMGVTMETHRSGNEV(MLY)VVI(MLY)GLHESQQEVLLEAVLFAAELMGVRVRIRF(MLY)GDTVTIVVREGSG

MSGSMKEEIKRLAEELKEKTKNEEIKRLAEEAAELAERSDDPEVLEVVKKALEEALKSKNEEKIELLLLVAVLVAEAGSVDAVEEKLEIALLALKLAEESKDPRIIRGALRAAIAALRSDDPLALKTVKEALERARASKDERLIRAILAAAYAFALLAVAGASAERLKEAEAIVKELIAAAEKGASPQELVLLVIEMMVKGMGVTMETHRSGNEVKVVIKGLHESQQEVLLEAVLFAAELMGVRVRIRFKGDTVTIVVREGSG
Protein #2 130 residues (96% resolved)

MSGEEAVRRRFEELLREALAFRERTGGRRETLEHAVRLARELAEFAASHPEFNRQEAVLLAIELMVRAMGVTMETHRSGNEV(MLY)VVI(MLY)GLNIDEQVALYRAVRETS(MLY)IMGVETEIEVEGDTQTIVVREGSG

MSGEEAVRRRFEELLREALAFRERTGGRRETLEHAVRLARELAEFAASHPEFNRQEAVLLAIELMVRAMGVTMETHRSGNEVKVVIKGLNIDEQVALYRAVRETSKIMGVETEIEVEGDTQTIVVREGSG
Non polymer #3 MPD

InChI=1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3/t5-/m0/s1

C[C@@H](CC(C)(C)O)O
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