2025-08-16_00000129|hard|8VX1

Cryo-EM Structure of DHX36 bound to the cMyc DNA G-quadruplex, Class 2; Electron microscopy 3.40Å
Protein #1 972 residues (89% resolved)

GGRGGRGRHPGHLKGREIGLWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLHSVQTKNDKDEEAQISWFAPEDHGYGTEAPAENKPNSVKNVEHQAAAMINQEKRPFRIRDKYIDRDSEYLLQENEPDATLDQQLLEDLQKKKTDLRYIEMQRFREKLPSYGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVVKDLLSYRPDLKVVLMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPEQKEHRSQFKKGFMQGHVNRQEKEEKEAIYKERWPGYLRELRQRYSASTVDVVEMMDDEKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFIIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFLSRLMDPPSNEAVLLSIKHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELAKDTKSDHLTVVNAFKGWEKAKQRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPQDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGVVAIHPKSVNVEQTEFNYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIIFQSPARIAHLVKELRKELDILLQEKIESPHPVDWKDTKSRDCAVLSAIIDLIKTQEKATPRNLPPRFQDGYYSPHHHHHHHH

GGRGGRGRHPGHLKGREIGLWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLHSVQTKNDKDEEAQISWFAPEDHGYGTEAPAENKPNSVKNVEHQAAAMINQEKRPFRIRDKYIDRDSEYLLQENEPDATLDQQLLEDLQKKKTDLRYIEMQRFREKLPSYGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVVKDLLSYRPDLKVVLMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPEQKEHRSQFKKGFMQGHVNRQEKEEKEAIYKERWPGYLRELRQRYSASTVDVVEMMDDEKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFIIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFLSRLMDPPSNEAVLLSIKHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELAKDTKSDHLTVVNAFKGWEKAKQRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPQDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGVVAIHPKSVNVEQTEFNYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIIFQSPARIAHLVKELRKELDILLQEKIESPHPVDWKDTKSRDCAVLSAIIDLIKTQEKATPRNLPPRFQDGYYSPHHHHHHHH
DNA #2 29 bases

(DA)(DG)(DG)(DG)(DT)(DG)(DG)(DG)(DT)(DA)(DG)(DG)(DG)(DT)(DG)(DG)(DG)(DT)(DT)(DT)(DG)(DT)(DT)(DT)(DT)(DT)(DT)(DT)(DT)

AGGGTGGGTAGGGTGGGTTTGTTTTTTTT
Download coordinates
Reference