2025-08-09_00000442|medium|9OX9

Cryo-EM structure of S. Mansoni p97 bound to CB-5083; Electron microscopy 2.85Å
Protein #1 839 residues (64% resolved)

MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFMCALNANPSNDPSSGEKVKFHRLIVDEPVKDDNSVVYLSQAKMDSMNLFRGDTVLVKGKKRKETVCVAIVDESCPDDKIRLNRCIRSNLRVKPGDIISIKSLPDILYGKRIHVLPIDDTIVGLTGNLYEAFLKPYFLAAYRPVHKGDIFIVRGGMRAVEFKVIETDPSPYCIVSPDTTIHTEGDPVKREDEEEKLNEIGYDDIGGCRKQLAQIKEMVELPLRHPQLFKAIGVKPPRGILLYGPPGTGKTLVARAVANESGSFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRSHVIVMAATNRPNSVDPALRRFGRFDREIEIGIPDSIGRLEILRIHTRNIRLAEDVELEKIANEAHGHVGADLASLCSEAALQQIRNKMNLIDLEDDTIDAEVLNSLAVTMDDFRWALGKSNPSALRETTVEVPNVTWDDIGGLENVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDIFDKARQAAPCVLFFDELDSIAKARGGSVGDAGGAADRVINQLLTEMDGMSAKKNVFIIGATNRPDIIDGAILRPGRLDQLIYIPLPDEASRVNILKANLRKSPIARDVDINFLAKATQGFSGADLTEICQRACKQAIRESIEAEIRAESEKKNKPNAMEDDFDPVPEITRRHFEEAMRFARRSVTENDVRKYEMFAQTLQQSRGIGNNFRFPGSDGSGIPTSTGGQGGGGSVYGSQNDAEDLYN

MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFMCALNANPSNDPSSGEKVKFHRLIVDEPVKDDNSVVYLSQAKMDSMNLFRGDTVLVKGKKRKETVCVAIVDESCPDDKIRLNRCIRSNLRVKPGDIISIKSLPDILYGKRIHVLPIDDTIVGLTGNLYEAFLKPYFLAAYRPVHKGDIFIVRGGMRAVEFKVIETDPSPYCIVSPDTTIHTEGDPVKREDEEEKLNEIGYDDIGGCRKQLAQIKEMVELPLRHPQLFKAIGVKPPRGILLYGPPGTGKTLVARAVANESGSFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRSHVIVMAATNRPNSVDPALRRFGRFDREIEIGIPDSIGRLEILRIHTRNIRLAEDVELEKIANEAHGHVGADLASLCSEAALQQIRNKMNLIDLEDDTIDAEVLNSLAVTMDDFRWALGKSNPSALRETTVEVPNVTWDDIGGLENVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDIFDKARQAAPCVLFFDELDSIAKARGGSVGDAGGAADRVINQLLTEMDGMSAKKNVFIIGATNRPDIIDGAILRPGRLDQLIYIPLPDEASRVNILKANLRKSPIARDVDINFLAKATQGFSGADLTEICQRACKQAIRESIEAEIRAESEKKNKPNAMEDDFDPVPEITRRHFEEAMRFARRSVTENDVRKYEMFAQTLQQSRGIGNNFRFPGSDGSGIPTSTGGQGGGGSVYGSQNDAEDLYN
Non polymer #2 JDP

InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)

Cc1cc2c(cccc2n1c3nc4c(c(n3)NCc5ccccc5)COCC4)C(=O)N
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Reference