2025-08-09_00000434|hard|9O4O

Cryo-EM structure of CR12044 Fab in complex with influenza virus neuraminidase from A/California/07/2009 (H1N1); Electron microscopy 2.53Å
Protein #1 127 residues (100% resolved)

EVQLVQSGSEVRKPGSTVKVSCKGSGGAFRTSVIHWVRQAPGQGLRWMGGIIPTLDTANHAQEFQGRATITADESTTTAYLELSSLRSEDSAVYYCATDYGGNSDRLGSYSFAFDVWGQGTTVTVSS

EVQLVQSGSEVRKPGSTVKVSCKGSGGAFRTSVIHWVRQAPGQGLRWMGGIIPTLDTANHAQEFQGRATITADESTTTAYLELSSLRSEDSAVYYCATDYGGNSDRLGSYSFAFDVWGQGTTVTVSS
Protein #2 110 residues (99% resolved)

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTQLTVL

QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTQLTVL
Protein #3 478 residues (81% resolved)

MYSMQLASCVTLTLVLLVNSQHHHHHHGSAWSHPQFEKGGSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSGGVKLAGNSSLCPVSGWAPLSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSVPIGSVPSPYNARFESIAWSASACHDGINWLTIGITGPDNGAVAILKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVMHPELTGLDCIVPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK

MYSMQLASCVTLTLVLLVNSQHHHHHHGSAWSHPQFEKGGSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSGGVKLAGNSSLCPVSGWAPLSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSVPIGSVPSPYNARFESIAWSASACHDGINWLTIGITGPDNGAVAILKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVMHPELTGLDCIVPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
Non polymer #4 CA

InChI=1S/Ca/q+2

[Ca+2]
Non polymer #5 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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