2025-07-26_00000308|ligand|9QSR

Protein Kinase CK2 and bivalent inhibitors; X-ray diffraction 2.83Å
Protein #1 359 residues (92% resolved)

MHHHHHHSSGVDLGTENLYFQSMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS

MHHHHHHSSGVDLGTENLYFQSMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS
Non polymer #2 A1I90

InChI=1S/C33H33ClN4O2/c34-30-19-23(11-13-26(30)24-9-5-4-6-10-24)21-35-16-7-2-1-3-8-17-37-32-28-15-18-36-22-29(28)27-14-12-25(33(39)40)20-31(27)38-32/h4-6,9-15,18-20,22,35H,1-3,7-8,16-17,21H2,(H,37,38)(H,39,40)

c1ccc(cc1)c2ccc(cc2Cl)CNCCCCCCCNc3c4ccncc4c5ccc(cc5n3)C(=O)O
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Reference