2025-07-26_00000304|ligand|9QRH

Protein Kinase CK2 and bivalent inhibitors; X-ray diffraction 2.59Å
Protein #1 359 residues (92% resolved)

MHHHHHHSSGVDLGTENLYFQSMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS

MHHHHHHSSGVDLGTENLYFQSMSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSS
Non polymer #2 A1I9M

InChI=1S/C28H25Cl2N5O4/c29-22-5-2-17(14-23(22)30)8-13-33-26(37)7-6-25(36)32-10-1-11-34-27-20-9-12-31-16-21(20)19-4-3-18(28(38)39)15-24(19)35-27/h2-5,9-10,12,14-16H,1,6-8,11,13H2,(H,33,37)(H,34,35)(H,38,39)/b32-10+

c1cc(c(cc1CCNC(=O)CCC(=O)/N=C/CCNc2c3ccncc3c4ccc(cc4n2)C(=O)O)Cl)Cl
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Reference