2025-07-26_00000132|ligand|9I4X

Toxoplasma gondii cytochrome bc1 complex from the respiratory supercomplex III2-IV inhibited by atovaquone and ELQ-300; Electron microscopy 2.79Å
Protein #1 368 residues (98% resolved)

MVSRTLSLFMSLFRAHLVFYRCALNLNSSYNFGFLVAMTFVLQIITGITLAFRYTSEASCAFASVQHLVREVAAGWEFRMLHATTASFVFLCILIHMTRGLYNWSYSYLTTAWMSGLVLYLLTIATAFLGYVLPWGQMSFWGATVITNLLSPIPYLVPWLLGGYYVSDVTLKRFFVLHFILPFIGCIIIVLHIFYLHLNGSSNPAGIDTALKVAFYPHMLMTDAKCLSYLIGLIFLQAAFGLMELSHPDNSIPVNRFVTPLHIVPEWYFLAYYAVLKVIPSKTGGLLVFMSSLINLGLLSEIRALNTRMLIRQQFMTRNVVSGWVIIWVYSMIFLIIIGSAIPQATYILYGRLATILYLTTGLVLCLY

MVSRTLSLFMSLFRAHLVFYRCALNLNSSYNFGFLVAMTFVLQIITGITLAFRYTSEASCAFASVQHLVREVAAGWEFRMLHATTASFVFLCILIHMTRGLYNWSYSYLTTAWMSGLVLYLLTIATAFLGYVLPWGQMSFWGATVITNLLSPIPYLVPWLLGGYYVSDVTLKRFFVLHFILPFIGCIIIVLHIFYLHLNGSSNPAGIDTALKVAFYPHMLMTDAKCLSYLIGLIFLQAAFGLMELSHPDNSIPVNRFVTPLHIVPEWYFLAYYAVLKVIPSKTGGLLVFMSSLINLGLLSEIRALNTRMLIRQQFMTRNVVSGWVIIWVYSMIFLIIIGSAIPQATYILYGRLATILYLTTGLVLCLY
Protein #2 398 residues (61% resolved)

MGGGGGGALNKLFPGYKDKIWMKVPVQWRQQMIQHWNKSYEKQVYSESVALNRTFQARNQLVLDRLKPSGAYRLPAVDYKRQLSRGTLVEGADFYLPTAQEQQRLARHFEPYSEQEQEERRKFRFQSISVYLAVALGASFVHDYFYQRRPVAWCLEKEPPHPPSYPFWFKSLFHSHDIPSVRRGYEVYRKVCATCHSMEQLHFRHLVGEVLPEKRVKQIAAEYDVTDGPNDQGEMYTRPGILGDAFPSPYPNEEAARYANGGAYPPDLSLITAARHFGPDYLMALLGGYRDPPEGVELRPGLYWNVWFPGNAIAMPPPLMDEMIDYEDGTPCNISQMSKDVVNFLTWATEPTADERKLYGLKCVSAIAIGTVLMTLWWRFYWAMYATRRIDFGKLKYL

MGGGGGGALNKLFPGYKDKIWMKVPVQWRQQMIQHWNKSYEKQVYSESVALNRTFQARNQLVLDRLKPSGAYRLPAVDYKRQLSRGTLVEGADFYLPTAQEQQRLARHFEPYSEQEQEERRKFRFQSISVYLAVALGASFVHDYFYQRRPVAWCLEKEPPHPPSYPFWFKSLFHSHDIPSVRRGYEVYRKVCATCHSMEQLHFRHLVGEVLPEKRVKQIAAEYDVTDGPNDQGEMYTRPGILGDAFPSPYPNEEAARYANGGAYPPDLSLITAARHFGPDYLMALLGGYRDPPEGVELRPGLYWNVWFPGNAIAMPPPLMDEMIDYEDGTPCNISQMSKDVVNFLTWATEPTADERKLYGLKCVSAIAIGTVLMTLWWRFYWAMYATRRIDFGKLKYL
Protein #3 487 residues (67% resolved)

MRHLARCASRRAVKWTERDSPVANFLRSSSCCPFQLLQASRAKIQRLRTSERFRLRSAQKLAPTRFPPFTHGPLFFSLPSRLTVPSSLRSLSAFSAPLSLPFRGTMAFLSSPLFAAKASLAARVHALGCSTTSLTSPLAARALAASSLSLFSVSPRRHFSVHSHNIRPDKHELPASEVPLYYNRFDQADHPSLWQLEEEQQRKHLDQEVTDVSQLVEPVSSPHQTEGWFKRLRYWHYKETAEPTFPRTPDLSKGELAAGATVTRTSVWHDPNEPAIVSVSRFAPDNFRAVGFAENVPNPESTNSDSHPDFREYRLGPGSVDRRPFVYFMSASYFFITASMMRSFLCKWVHYWWVSRDMLAAGTTEVDLRPIQEGMTAVFKWRGKPVFVRHRTAEDIAKAQADDALIGTMKDPQLDSERCPRPQWLINIGVCTHLGCIPTDGGNYGGWFCPCHGSHYDTSGRIRLGPAPSNLELPPTVFLDDHTVKLG

MRHLARCASRRAVKWTERDSPVANFLRSSSCCPFQLLQASRAKIQRLRTSERFRLRSAQKLAPTRFPPFTHGPLFFSLPSRLTVPSSLRSLSAFSAPLSLPFRGTMAFLSSPLFAAKASLAARVHALGCSTTSLTSPLAARALAASSLSLFSVSPRRHFSVHSHNIRPDKHELPASEVPLYYNRFDQADHPSLWQLEEEQQRKHLDQEVTDVSQLVEPVSSPHQTEGWFKRLRYWHYKETAEPTFPRTPDLSKGELAAGATVTRTSVWHDPNEPAIVSVSRFAPDNFRAVGFAENVPNPESTNSDSHPDFREYRLGPGSVDRRPFVYFMSASYFFITASMMRSFLCKWVHYWWVSRDMLAAGTTEVDLRPIQEGMTAVFKWRGKPVFVRHRTAEDIAKAQADDALIGTMKDPQLDSERCPRPQWLINIGVCTHLGCIPTDGGNYGGWFCPCHGSHYDTSGRIRLGPAPSNLELPPTVFLDDHTVKLG
Protein #4 509 residues (90% resolved)

MMFRFLPRVASGASSLSVSQRRLRASFSSSLQSRGFFSAAPAAATAGVSPLARSVDAAIPEEAFNQPPTLTTTLPNGIRVATQRLPFHQTATVGVWIDSGSRYDTKETNGAAHFLEHMTFKGTKRRSRIQLEQEIENMGAHLNAYTSREQTVYYAKAFKKDIPQCVDILSDILLNSTIDEEAVQMEKHVILREMEEVERQTEEVIFDRLHTTAFRDSPLGYTILGPEENIRNMTREHILEYINRNYTSDRMVVAAAGDVDHKELTALVEKHFAGLPQPKRSKIILPTEKPFFCGSELLHRNDDMGPTAHVAVGFEGVPWKSPDAVTFMLMQAIVGSYRKHDEGIVPGKVSANATVRNVCNKMTVGCADMFSAFNTCYSDTGLFGFYAQCDEVALEHCVMEIMFGITSLSYAVTDEEVERAKAQLKTQLLGHLDSTTAVAEDIGRQMLAYGRRMPLAEFLKRLEVIDAEEVKRVAWKYLHDAEVAVAGLGPLFGMPQLINLRRATFWLRY

MMFRFLPRVASGASSLSVSQRRLRASFSSSLQSRGFFSAAPAAATAGVSPLARSVDAAIPEEAFNQPPTLTTTLPNGIRVATQRLPFHQTATVGVWIDSGSRYDTKETNGAAHFLEHMTFKGTKRRSRIQLEQEIENMGAHLNAYTSREQTVYYAKAFKKDIPQCVDILSDILLNSTIDEEAVQMEKHVILREMEEVERQTEEVIFDRLHTTAFRDSPLGYTILGPEENIRNMTREHILEYINRNYTSDRMVVAAAGDVDHKELTALVEKHFAGLPQPKRSKIILPTEKPFFCGSELLHRNDDMGPTAHVAVGFEGVPWKSPDAVTFMLMQAIVGSYRKHDEGIVPGKVSANATVRNVCNKMTVGCADMFSAFNTCYSDTGLFGFYAQCDEVALEHCVMEIMFGITSLSYAVTDEEVERAKAQLKTQLLGHLDSTTAVAEDIGRQMLAYGRRMPLAEFLKRLEVIDAEEVKRVAWKYLHDAEVAVAGLGPLFGMPQLINLRRATFWLRY
Protein #5 563 residues (86% resolved)

MNASILFRRNAPGVSTCLRRRCLRPAALAAASASGVSTPASGVWTPAFQRTEKRFLSGAALQPKAGPAPEYRRVPFVKEDMEKVMEEVPEFKYYYVGKENTKGNVYEGIPLDQSILEPADLRDYVPPHSNIQYSKLDNGLRIASMDRGGLTASLGLFVHAGTRFEDVTNFGVTHMIQNLAFASTAHLSLLRTVKTIEVLGANAGCVVGREHLVYSAECLRSHMPLLVPMLTGNVLFPRFLPWELKACKEKLIMARKRLEHMPDQMVSELLHTTAWHNNTLGHKLHCTERSLGHYNPDVIRHYMLQHFSPENMVFVGVNVNHDELCTWLMRAFVDYNAIPPSKRTVASPVYTGGDVRLETPSPHAHMAIAFETPGGWNGGDLVAYSVLQTILGGGGAFSTGGPGKGMYTRLYLNVLNQNEWVESAMAFNTQYTDSGIFGLYMLADPTKSANAVKVMAEQFGKMGSVTKEELQRAKNSLKSSIFMNLECRGIVMEDVGRQLLMSNRVISPQEFCTAIDAVTEADIKRVVDAMYKKPPTVVAYGDVSTVPHYEEVRAALRAAGVGK

MNASILFRRNAPGVSTCLRRRCLRPAALAAASASGVSTPASGVWTPAFQRTEKRFLSGAALQPKAGPAPEYRRVPFVKEDMEKVMEEVPEFKYYYVGKENTKGNVYEGIPLDQSILEPADLRDYVPPHSNIQYSKLDNGLRIASMDRGGLTASLGLFVHAGTRFEDVTNFGVTHMIQNLAFASTAHLSLLRTVKTIEVLGANAGCVVGREHLVYSAECLRSHMPLLVPMLTGNVLFPRFLPWELKACKEKLIMARKRLEHMPDQMVSELLHTTAWHNNTLGHKLHCTERSLGHYNPDVIRHYMLQHFSPENMVFVGVNVNHDELCTWLMRAFVDYNAIPPSKRTVASPVYTGGDVRLETPSPHAHMAIAFETPGGWNGGDLVAYSVLQTILGGGGAFSTGGPGKGMYTRLYLNVLNQNEWVESAMAFNTQYTDSGIFGLYMLADPTKSANAVKVMAEQFGKMGSVTKEELQRAKNSLKSSIFMNLECRGIVMEDVGRQLLMSNRVISPQEFCTAIDAVTEADIKRVVDAMYKKPPTVVAYGDVSTVPHYEEVRAALRAAGVGK
Protein #6 89 residues (99% resolved)

MSYPYYCEFFVKFPNYIPPKDPAERLVDPRQKLEPGCTARCSLWVNEYDACTKRVRARTDNKGNCSGQYEELHVCIDRCVAKDIFKYLK

MSYPYYCEFFVKFPNYIPPKDPAERLVDPRQKLEPGCTARCSLWVNEYDACTKRVRARTDNKGNCSGQYEELHVCIDRCVAKDIFKYLK
Protein #7 234 residues (82% resolved)

MAQFHREIGKLFASYSNKITANSPVQYVPSPPTKGKVRRALSSALMPVWFKFFRGPLDRWNLAVMAKYLRDHGLMYDDLYSDKEPVFARALELLPPDIQAARFRRLMRGTYLNHLRLYLPVHEQNYDPFIPYMAPYVEEAKFQLQEEEELLGYHMWEGVWYSGGVTGFGDKEPGEHFLVALPNLYGAGGSPMQAGGKHFSSHAASAARARLATLAQKRLEEAMQQRERQSVSQN

MAQFHREIGKLFASYSNKITANSPVQYVPSPPTKGKVRRALSSALMPVWFKFFRGPLDRWNLAVMAKYLRDHGLMYDDLYSDKEPVFARALELLPPDIQAARFRRLMRGTYLNHLRLYLPVHEQNYDPFIPYMAPYVEEAKFQLQEEEELLGYHMWEGVWYSGGVTGFGDKEPGEHFLVALPNLYGAGGSPMQAGGKHFSSHAASAARARLATLAQKRLEEAMQQRERQSVSQN
Protein #8 122 residues (79% resolved)

MAASRLCQYLAGRGQTGLLSLSAPRLGAPKFERKMLGSYPVSPEFEMVWRDRLTAHGGYIQQTISPYQLKFIYPFWHTFFARCWCKCSAYAWPWVWPGLITFGLVKKMNHDVEEDIRDHYWY

MAASRLCQYLAGRGQTGLLSLSAPRLGAPKFERKMLGSYPVSPEFEMVWRDRLTAHGGYIQQTISPYQLKFIYPFWHTFFARCWCKCSAYAWPWVWPGLITFGLVKKMNHDVEEDIRDHYWY
Protein #9 128 residues (72% resolved)

MHFSGVFLRTSRVFLASESSAAGSKVAKSLPGIRFGNPWRDDYPEWIWKSLRVSRKDKDMFAPFFKLLNATKLYEYCLKDNRRYCMFVMGVGLVSSWMWSEWWNSVWRRINKGKLYNDVPYVYPEEDE

MHFSGVFLRTSRVFLASESSAAGSKVAKSLPGIRFGNPWRDDYPEWIWKSLRVSRKDKDMFAPFFKLLNATKLYEYCLKDNRRYCMFVMGVGLVSSWMWSEWWNSVWRRINKGKLYNDVPYVYPEEDE
Protein #10 80 residues (93% resolved)

MSRAVYAKLWASTAQYTQRRHYAWYQIWSRVIPWSVPWGIFAMWMVFPAMPVEYRQALTFGIWQKPNIGTHGPDPADAKK

MSRAVYAKLWASTAQYTQRRHYAWYQIWSRVIPWSVPWGIFAMWMVFPAMPVEYRQALTFGIWQKPNIGTHGPDPADAKK
Protein #11 141 residues (55% resolved)

MATHNCLRQTAAQMLGQNANVFRFFSKSAPSRPSGNVALESVKNAAVAETETFAGRANVAAGTGKLEGSLLPPPHIPGIRRAPREPASPKMAGMEGRMPVRLPPEGSRFRQYVDPRADVYFPLTAVLVTLGPLYMFSKAFF

MATHNCLRQTAAQMLGQNANVFRFFSKSAPSRPSGNVALESVKNAAVAETETFAGRANVAAGTGKLEGSLLPPPHIPGIRRAPREPASPKMAGMEGRMPVRLPPEGSRFRQYVDPRADVYFPLTAVLVTLGPLYMFSKAFF
Protein #12 109 residues (37% resolved)

MNCPNLPAPEEFVVPVFSAGPPVGKNCFHCGIRLRRGHSSPTYSFPPYCVTMSYGNGTVLMPIVRRVFIGALVGIYAYAATDVVLIPGYAQLMQKWKKGSSTPAHGGGH

MNCPNLPAPEEFVVPVFSAGPPVGKNCFHCGIRLRRGHSSPTYSFPPYCVTMSYGNGTVLMPIVRRVFIGALVGIYAYAATDVVLIPGYAQLMQKWKKGSSTPAHGGGH
Non polymer #13 A1IJD

InChI=1S/C24H17ClF3NO4/c1-13-22(23(30)18-11-19(25)21(31-2)12-20(18)29-13)14-3-5-15(6-4-14)32-16-7-9-17(10-8-16)33-24(26,27)28/h3-12H,1-2H3,(H,29,30)

CC1=C(C(=O)c2cc(c(cc2N1)OC)Cl)c3ccc(cc3)Oc4ccc(cc4)OC(F)(F)F
Non polymer #14 AOQ

InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2/t13-,15-

c1ccc2c(c1)C(=O)C(=C(C2=O)O)C3CCC(CC3)c4ccc(cc4)Cl
Non polymer #15 CDL

InChI=1S/C81H158O17P2/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2/h75-77,82H,5-74H2,1-4H3,(H,87,88)(H,89,90)/p-2/t76-,77-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC(COP(=O)([O-])OC[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC)O)OC(=O)CCCCCCCCCCCCCCCCC
Non polymer #16 FES

InChI=1S/2Fe.2S

S1[Fe]S[Fe]1
Non polymer #17 HEC

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,9-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;+4/b21-7?,22-8?,26-13-,29-14-,30-15-,31-16-;

CC=C1C(=C2C=C3C(=CC)C(=C4N3[Fe]56N2C1=Cc7n5c(c(c7C)CCC(=O)O)C=C8N6C(=C4)C(=C8CCC(=O)O)C)C)C
Non polymer #18 HEM

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
Non polymer #19 PC1

InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
Non polymer #20 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference