2025-07-26_00000102|ligand|9G7B

CryoEM structure of human rho1 GABAA receptor in complex with GABA and loreclezole; Electron microscopy 2.18Å

Protein #1 479 residues (67% resolved)

Raw Sequence ...

MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS

Canonical Sequence ...

Non polymer #2 A1IIV

InChI=1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-

SMILES: c1cc(c(cc1Cl)Cl)/C(=C/n2cncn2)/Cl

c1cc(c(cc1Cl)Cl)/C(=C/n2cncn2)/Cl

Non polymer #3 ABU

InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

SMILES: C(CC(=O)O)CN

C(CC(=O)O)CN

Non polymer #4 CL

InChI=1S/ClH/h1H/p-1

SMILES: [Cl-]

[Cl-]

Non polymer #5 HEX

InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3

SMILES: CCCCCC

CCCCCC

Non polymer #6 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

Non polymer #7 OCT

InChI=1S/C8H18/c1-3-5-7-8-6-4-2/h3-8H2,1-2H3

SMILES: CCCCCCCC

CCCCCCCC

Biounit #1 homo-pentamer

Reference