2025-07-19_00000102|hard|9I8Y

SpCas12Cas12f1 in complex with sgRNA and cognate DNA; Electron microscopy 2.89Å
Protein #1 500 residues (82% resolved)

SNAMGESVKAIKLKILDMFLDPECTKQDDNWRKDLSTMSRFCAEAGNMCLRDLYNYFSMPKEDRISSKDLYNAMYHKTKLLHPELPGKVANQIVNHAKDVWKRNAKLIYRNQISMPTYKITTAPIRLQNNIYKLIKNKNKYIIDVQLYSKEYSKDSGKGTHRYFLVAVRDSSTRMIFDRIMSKDHIDSSKSYTQGQLQIKKDHQGKWYCIIPYTFPTHETVLDPDKVMGVDLGVAKAVYWAFNSSYKRGCIDGGEIEHFRKMIRARRVSIQNQIKHSGDARKGHGRKRALKPIETLSEKEKNFRDTINHRYANRIVEAAIKQGCGTIQIENLEGIADTTGSKFLKNWPYYDLQTKIVNKAKEHGITVVAINPQYTSQRCSMCGYIEKTNRSSQAVFECKQCGYGSRTICINCRHVQVSGDVCEECGGIVKKENVNADYNAAKNISTPYIDQIIMEKCLELGIPYRSITCKECGHIQASGNTCEVCGSTNILKPKKIRKAK

SNAMGESVKAIKLKILDMFLDPECTKQDDNWRKDLSTMSRFCAEAGNMCLRDLYNYFSMPKEDRISSKDLYNAMYHKTKLLHPELPGKVANQIVNHAKDVWKRNAKLIYRNQISMPTYKITTAPIRLQNNIYKLIKNKNKYIIDVQLYSKEYSKDSGKGTHRYFLVAVRDSSTRMIFDRIMSKDHIDSSKSYTQGQLQIKKDHQGKWYCIIPYTFPTHETVLDPDKVMGVDLGVAKAVYWAFNSSYKRGCIDGGEIEHFRKMIRARRVSIQNQIKHSGDARKGHGRKRALKPIETLSEKEKNFRDTINHRYANRIVEAAIKQGCGTIQIENLEGIADTTGSKFLKNWPYYDLQTKIVNKAKEHGITVVAINPQYTSQRCSMCGYIEKTNRSSQAVFECKQCGYGSRTICINCRHVQVSGDVCEECGGIVKKENVNADYNAAKNISTPYIDQIIMEKCLELGIPYRSITCKECGHIQASGNTCEVCGSTNILKPKKIRKAK
DNA #2 32 bases

(DG)(DG)(DC)(DG)(DA)(DC)(DG)(DT)(DT)(DG)(DG)(DG)(DT)(DC)(DA)(DA)(DC)(DT)(DG)(DA)(DA)(DA)(DT)(DA)(DC)(DG)(DC)(DT)(DA)(DC)(DG)(DC)

GGCGACGTTGGGTCAACTGAAATACGCTACGC
DNA #3 19 bases

(DG)(DC)(DG)(DT)(DA)(DG)(DC)(DG)(DT)(DA)(DT)(DT)(DT)(DC)(DT)(DC)(DA)(DA)(DC)

GCGTAGCGTATTTCTCAAC
RNA #4 210 bases

GGGAUUUACUCUGUUUCGCGCGCCAGGGCAGUUAGGUGCCCUAAAAGAGCGAAGUGGCCGAAAGGAAAGGCUAACGCUUCUCUAACGCUACGGCGACCUUGGCGAAAUGCCAUCAAUACCACGCGGCCCGAAAGGGUUCGCGCGAAACUGAGUAAUGAAAGUCGCAUCUUGCGUAAGCGCGUGGAUUGAAACAGUUGACCCAACGUCGCC

GGGAUUUACUCUGUUUCGCGCGCCAGGGCAGUUAGGUGCCCUAAAAGAGCGAAGUGGCCGAAAGGAAAGGCUAACGCUUCUCUAACGCUACGGCGACCUUGGCGAAAUGCCAUCAAUACCACGCGGCCCGAAAGGGUUCGCGCGAAACUGAGUAAUGAAAGUCGCAUCUUGCGUAAGCGCGUGGAUUGAAACAGUUGACCCAACGUCGCC
Non polymer #5 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference