2025-07-19_00000054|ligand|9EWD

DNA Polymerase Lambda I493K E529D, TMP:At Ca2+ Ground State Ternary Complex; X-ray diffraction 2.12Å
Protein #1 330 residues (97% resolved)

GAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIKVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSDHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW

GAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIKVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSDHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
DNA #2 4 bases

(DG)(DC)(DC)(DG)

GCCG
DNA #3 6 bases

(DC)(DA)(DG)(DT)(DA)(DC)

CAGTAC
DNA #4 11 bases

(DC)(DG)(DG)(DC)(DA)(DG)(DT)(DA)(DC)(DT)(DG)

CGGCAGTACTG
Non polymer #5 CA

InChI=1S/Ca/q+2

[Ca+2]
Non polymer #6 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
Non polymer #7 K

InChI=1S/K/q+1

[K+]
Non polymer #8 NA

InChI=1S/Na/q+1

[Na+]
Non polymer #9 TMP

InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COP(=O)(O)O)O
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Reference