2025-07-19_00000014|hard|8XXG

Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the reaction intermediate derived from the crystal soaked into the solution at pH 4.0 under 277 K for 2.5 hours; X-ray diffraction 1.82Å
DNA #1 8 bases

(DA)(DG)(DC)(DG)(DT)(DC)(DC)(DA)

AGCGTCCA
DNA #2 16 bases

(DT)(DG)(DG)(DT)(DA)(DG)(DA)(DC)(DC)(DT)(DG)(DG)(DA)(DC)(DG)(DC)

TGGTAGACCTGGACGC
Protein #3 336 residues (94% resolved)

GPGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTHVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG

GPGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTHVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
DNA #4 7 bases

(DG)(DT)(DC)(DT)(DA)(DC)(DC)

GTCTACC
Non polymer #5 A1LXK

InChI=1S/C10H16N5O9P/c11-9-13-7-6(8(19)14-9)12-10(20)15(7)5(18)1-3(16)4(17)2-24-25(21,22)23/h3-5,16-18H,1-2H2,(H,12,20)(H2,21,22,23)(H3,11,13,14,19)/t3-,4+,5-/m0/s1

C([C@@H]([C@@H](COP(=O)(O)O)O)O)[C@@H](N1C2=C(C(=O)NC(=N2)N)NC1=O)O
Non polymer #6 MG

InChI=1S/Mg/q+2

[Mg+2]
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Reference