2025-07-12_00000178|medium|9JGK

cryo-EM structure of 5-Hydroxytryptamine 2B Receptor in complex with balovaptan; Electron microscopy 3.60Å
Protein #1 568 residues (66% resolved)

DYKDDDAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIRFRRRGAEALERAFSLEDDKEALLAALDALAEAFADDAELTALLALLRRLLEDPDLPADELAALRAALTRFPEFREALLALLDRYLATRDLADARDLVWALVLAIASDPRYRPAVAAMIAFGDAEVLRAGLLRGAEALGLPGGEALVEEIMAEAENEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVHHHHHH

DYKDDDAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIRFRRRGAEALERAFSLEDDKEALLAALDALAEAFADDAELTALLALLRRLLEDPDLPADELAALRAALTRFPEFREALLALLDRYLATRDLADARDLVWALVLAIASDPRYRPAVAAMIAFGDAEVLRAGLLRGAEALGLPGGEALVEEIMAEAENEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVHHHHHH
Non polymer #2 A1EB7

InChI=1S/C22H24ClN5O/c1-27-13-16-12-17(23)7-10-19(16)28-20(14-27)25-26-22(28)15-5-8-18(9-6-15)29-21-4-2-3-11-24-21/h2-4,7,10-12,15,18H,5-6,8-9,13-14H2,1H3/t15-,18-

CN1Cc2cc(ccc2-n3c(nnc3C4CCC(CC4)Oc5ccccn5)C1)Cl
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Reference