2025-07-05_00000258
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ligand
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9O91
Structure of IKZF2:CRBN:Compound 5 ternary structure;
X-ray diffraction 1.86Å
Protein #1
111 residues (100% resolved)
Raw Sequence ...
GPSTSLSCKQCQETEITTKNEIFSLSLSGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTI
Canonical Sequence ...
GPSTSLSCKQCQETEITTKNEIFSLSLSGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTI
Protein #2
30 residues (90% resolved)
Raw Sequence ...
GGERPFHCNQCGASFTQKGNLLRHIKLHSG
Canonical Sequence ...
GGERPFHCNQCGASFTQKGNLLRHIKLHSG
Non polymer #3
A1CAC
InChI=1S/C25H25N5O3/c31-22-6-5-21(24(32)28-22)30-14-16-11-15(3-4-19(16)25(30)33)20-12-17(13-29-9-1-2-10-29)18-7-8-26-23(18)27-20/h3-4,7-8,11-12,21H,1-2,5-6,9-10,13-14H2,(H,26,27)(H,28,31,32)/t21-/m0/s1
InChI=1S/C25H25N5O3/c31-22-6-5-21(24(32)28-22)30-14-16-11-15(3-4-19(16)25(30)33)20-12-17(13-29-9-1-2-10-29)18-7-8-26-23(18)27-20/h3-4,7-8,11-12,21H,1-2,5-6,9-10,13-14H2,(H,26,27)(H,28,31,32)/t21-/m0/s1
SMILES: c1cc2c(cc1c3cc(c4cc[nH]c4n3)CN5CCCC5)CN(C2=O)[C@H]6CCC(=O)NC6=O
c1cc2c(cc1c3cc(c4cc[nH]c4n3)CN5CCCC5)CN(C2=O)[C@H]6CCC(=O)NC6=O
Non polymer #4
ZN
InChI=1S/Zn/q+2
InChI=1S/Zn/q+2
SMILES: [Zn+2]
[Zn+2]
Biounit #1
hetero-1-1-mer
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Biounit #2
hetero-1-1-mer
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Biounit #3
hetero-1-1-mer
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Biounit #4
hetero-1-1-mer
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Model
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