2025-06-28_00000123|medium|9H8T

Cryo-EM structure of the atovaquone-inhibited Complex III from the Chlorocebus sabaeus respirasome; Electron microscopy 2.67Å
Protein #1 325 residues (74% resolved)

MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVVLSALGMLAAGGAGLAVALHSAVSASDVALHPPSYPWSHSGFLSSLDHTSIRRGFQVYKQVCSSCHSMNFVAYRHLVGVCYTEDEAKALAAEVEVQDGPNENGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIARARHGGEDYIFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMALKMLTMMALLIPLTYIMKRHKWSVLKSRKLAYRPPK

MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVVLSALGMLAAGGAGLAVALHSAVSASDVALHPPSYPWSHSGFLSSLDHTSIRRGFQVYKQVCSSCHSMNFVAYRHLVGVCYTEDEAKALAAEVEVQDGPNENGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIARARHGGEDYIFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMALKMLTMMALLIPLTYIMKRHKWSVLKSRKLAYRPPK
Protein #2 274 residues (72% resolved)

MLSVAARSGPFAPVLSATSRGVAGALRPLVQATVPATPEPPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDVKVPDFYDYRRLEVLDSTKSSRESSEARKGFSYLVTAVTTVGVAYAAKNVVTQFISSMSASADVLAMAKIEINLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPPYEFTRDDMVVVG

MLSVAARSGPFAPVLSATSRGVAGALRPLVQATVPATPEPPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDVKVPDFYDYRRLEVLDSTKSSRESSEARKGFSYLVTAVTTVGVAYAAKNVVTQFISSMSASADVLAMAKIEINLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPPYEFTRDDMVVVG
Protein #3 111 residues (94% resolved)

MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLLRDDTMYEDEDVKEAIRRLPDNLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK

MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLLRDDTMYEDEDVKEAIRRLPDNLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK
Protein #4 82 residues (99% resolved)

MGREFGNLTRIRHVISYSLSPLEQRALPHVLSKGVPNMLRRVRESFFRVVPQFVVFYLLYTWGTEEFEKSKRKNPAAYENDK

MGREFGNLTRIRHVISYSLSPLEQRALPHVLSKGVPNMLRRVRESFFRVVPQFVVFYLLYTWGTEEFEKSKRKNPAAYENDK
Protein #5 63 residues (89% resolved)

MAAVAFTSKLYSLLFRRTSTFALTIVVGVLFFERAFDQGADAIYDHINEGKLWKHIKHKYENK

MAAVAFTSKLYSLLFRRTSTFALTIVVGVLFFERAFDQGADAIYDHINEGKLWKHIKHKYENK
Protein #6 91 residues (74% resolved)

MGLEDERKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSHTEEDCMEELLDFLYARDHCVAHKLFNNLK

MGLEDERKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSHTEEDCMEELLDFLYARDHCVAHKLFNNLK
Protein #7 453 residues (92% resolved)

MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYAPLSRIGLFIKAGSRYEDSNNLGTTHLLRLASSLTTKGASSFKITRGIEAVGSKLSVTATRETMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGFGLSGVKAKYRGGEIREQNGDSLVHAALVAESAVAGSAEANAFSVLQHVLGAGPHIKRGSNTTSHLYQAVAKATQQPFDVSAFNANYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSERFLEEVGSQALVAGSYVPPSTVLQQIDSVANADVINAAKKFVSGQKSMVASGNLGHTPFVDEL

MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYAPLSRIGLFIKAGSRYEDSNNLGTTHLLRLASSLTTKGASSFKITRGIEAVGSKLSVTATRETMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGFGLSGVKAKYRGGEIREQNGDSLVHAALVAESAVAGSAEANAFSVLQHVLGAGPHIKRGSNTTSHLYQAVAKATQQPFDVSAFNANYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSERFLEEVGSQALVAGSYVPPSTVLQQIDSVANADVINAAKKFVSGQKSMVASGNLGHTPFVDEL
Protein #8 380 residues (99% resolved)

MTPMRKSNPIMKMINHSLIDLPTPSNISMWWNFGSLLAFCLILQIITGLFLAMHYSPDTSSAFSSIAHITRDVNHGWIIRYLHANGASMFFICLFLHVGRGLYYGSFLLLKTWNTGIMLLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSIGNPTLSRFFTLHFILPFIITALTMVHLLFLHETGSNNPCGISSDSDKIPFHPYYTIKDILGLVLLLFILTTLTLLSPNLLNDPDNYIPADPLNTPPHIKPEWYFLFAYAILRSVPNKLGGVLALFLSILILSIIPTLHNSKQQSMMFRPLSQFLFWFLITTLLTLTWIGSQPVSQPFIFIGQLASTMYFTTVLILMPLTSLIENNLLKWT

MTPMRKSNPIMKMINHSLIDLPTPSNISMWWNFGSLLAFCLILQIITGLFLAMHYSPDTSSAFSSIAHITRDVNHGWIIRYLHANGASMFFICLFLHVGRGLYYGSFLLLKTWNTGIMLLFLTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSIGNPTLSRFFTLHFILPFIITALTMVHLLFLHETGSNNPCGISSDSDKIPFHPYYTIKDILGLVLLLFILTTLTLLSPNLLNDPDNYIPADPLNTPPHIKPEWYFLFAYAILRSVPNKLGGVLALFLSILILSIIPTLHNSKQQSMMFRPLSQFLFWFLITTLLTLTWIGSQPVSQPFIFIGQLASTMYFTTVLILMPLTSLIENNLLKWT
Protein #9 480 residues (88% resolved)

MAASVVCRAATSGAQVLLRARRSPTLLRTPALRSTATFAQALQFVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKVVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMRDVVFDYLHATAFQGTPLAQTVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQQLLDLAQKHLGDIPWTYAEDTMPALTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPDNVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYADTGLLGAHFVCDRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF

MAASVVCRAATSGAQVLLRARRSPTLLRTPALRSTATFAQALQFVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKVVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMRDVVFDYLHATAFQGTPLAQTVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQQLLDLAQKHLGDIPWTYAEDTMPALTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPDNVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYADTGLLGAHFVCDRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF
Protein #10 56 residues (80% resolved)

MMTRFLGPRYRQLVKNWIPTAYTWGAVGTLGLAWAADWRLILDWVPYVNGRFKKDD

MMTRFLGPRYRQLVKNWIPTAYTWGAVGTLGLAWAADWRLILDWVPYVNGRFKKDD
Non polymer #11 AFI

InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,25-26H,5-8H2/t13-

c1ccc2c(c1)C(=C(C(=C3CCC(CC3)c4ccc(cc4)Cl)C2=O)O)O
Non polymer #12 AOQ

InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2/t13-,15-

c1ccc2c(c1)C(=O)C(=C(C2=O)O)C3CCC(CC3)c4ccc(cc4)Cl
Non polymer #13 CDL

InChI=1S/C81H158O17P2/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2/h75-77,82H,5-74H2,1-4H3,(H,87,88)(H,89,90)/p-2/t76-,77-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC(COP(=O)([O-])OC[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC)O)OC(=O)CCCCCCCCCCCCCCCCC
Non polymer #14 FES

InChI=1S/2Fe.2S

S1[Fe]S[Fe]1
Non polymer #15 HEC

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,9-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;+4/b21-7?,22-8?,26-13-,29-14-,30-15-,31-16-;

CC=C1C(=C2C=C3C(=CC)C(=C4N3[Fe]56N2C1=Cc7n5c(c(c7C)CCC(=O)O)C=C8N6C(=C4)C(=C8CCC(=O)O)C)C)C
Non polymer #16 HEM

InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
Non polymer #17 PC1

InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
Non polymer #18 PEE

InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

CCCCCCCC/C=CCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=CCCCCCCCC
Non polymer #19 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference