2025-06-14_00000298|ligand|9QAC

Crystal structure of the SMARCA2 bromodomain bound to a fragment screening hit; X-ray diffraction 2.07Å
Protein #1 123 residues (93% resolved)

SMAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEE

SMAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEE
Non polymer #2 A1I5P

InChI=1S/C10H10N2O2/c1-14-10(13)8-6-4-2-3-5-7(6)12-9(8)11/h2-5,12H,11H2,1H3

COC(=O)c1c2ccccc2[nH]c1N
Non polymer #3 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference