2025-06-14_00000189|medium|9JMI

Cryo-EM structure of CN-HedgehogCoV (HKU31/Erinaceus amurensis/China/2014) S-trimer in a locked-2 conformation; Electron microscopy 3.30Å
Protein #1 1349 residues (84% resolved)

MIRSVFLLMCLLTLIKSGDANCIVVDMQPSYFQRDWPRPINMSAADGIIYPVGRTYANITIMLSGLFPHQADKGKQYIYSMYHMKFNQGVNDPFISNYSYYTEPFDNGFVVRIGANSNITGSSVVGSANATVKKIYPALMLGSVVGKFPSNKTGRYFNHTLVILPEKCGTQITALYCVLQPKNQTNCTGHTTYTSYVLVENKTCSTDADGNLKQSLQTWFDLKDCLFEKKYNVSADEREEWFGITQDQQGVHLYTSRKNGFKSNNMFLFATLPIYERLRYYTVMPRSIKTTANNDHMAWSAFYIYQLHKLNYLVEFDVEGYIVRASDCGANDYTQLQCSYGQFDMNSGVYSASYFNAQPRGYYYVANELEECALDVLFKNIAPQIANYSRRVFTNCNYNLTKLLSLVEVDEFVCDKTTPESLATGCYSSLVVDWFALPLSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHATINSNVSSSLNFTANNNYAYISRCQGTDGKPILLQKGQLPNIACRSGVLGLSNDVDYFGYNFNGRIFYIGRKSYTPRTSEGSIQMVYVITANYAEGPNNVCPLKDTTTATDNLDSLLGQCIDYDINGVVGQGVFQKCNSTGIPSQVFVYDSFHNIIGYHSKNGTYYCMAPCVSVPVSVIYDKSSNSHATLYGSVACDHIKMIPSVLSRETATKLRASDNGLLQTAVGCVIGFHNTSDTVEDCNLPLGQSLCAKPPSLTRSANNTFGLAVMKYENPLKVEVLNSSEFEISVPTNFSFRVTEEFIETSIQKVTVDCKQYVCNGFERCEQLLEQYGQFCAKINQALHGVNLRQDDATKSLFESIRVPQSAPLMASLSGDYNLSLFETPSINTGGSGNYRSALEDLLFDKVTLSVPGYMKGYDECMKKGPPSARDLICAQYVAGYKVLPPLYDSNMEAMYTASLTGSIAGALWTGGLSSAASLPFAQSIYYRMNGIGITQNVLMENQKLIANKFNQALGAMQTGFTTTNQAFQKVQDAVNANAQALSKLASELSNTFGAISASIGDILKRLDTLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLVKDKVNECVKSQSSRNGFCGQGTHIVSFAVNAPNGFYFVHVGYHPTDYVNQTSAYGLCDSSNTKCIAAKNGYFIKNGSDDWMFTGSSYYQPEPITNFNSRSVEPEVTFQNLTNNLPPPLSNSTDVDFKDELEEFFKNITSEVPNFGSITQINSTVLDLSEEMKTLQSVVEALNQSYIELKELGNYTYYNKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA

MIRSVFLLMCLLTLIKSGDANCIVVDMQPSYFQRDWPRPINMSAADGIIYPVGRTYANITIMLSGLFPHQADKGKQYIYSMYHMKFNQGVNDPFISNYSYYTEPFDNGFVVRIGANSNITGSSVVGSANATVKKIYPALMLGSVVGKFPSNKTGRYFNHTLVILPEKCGTQITALYCVLQPKNQTNCTGHTTYTSYVLVENKTCSTDADGNLKQSLQTWFDLKDCLFEKKYNVSADEREEWFGITQDQQGVHLYTSRKNGFKSNNMFLFATLPIYERLRYYTVMPRSIKTTANNDHMAWSAFYIYQLHKLNYLVEFDVEGYIVRASDCGANDYTQLQCSYGQFDMNSGVYSASYFNAQPRGYYYVANELEECALDVLFKNIAPQIANYSRRVFTNCNYNLTKLLSLVEVDEFVCDKTTPESLATGCYSSLVVDWFALPLSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHATINSNVSSSLNFTANNNYAYISRCQGTDGKPILLQKGQLPNIACRSGVLGLSNDVDYFGYNFNGRIFYIGRKSYTPRTSEGSIQMVYVITANYAEGPNNVCPLKDTTTATDNLDSLLGQCIDYDINGVVGQGVFQKCNSTGIPSQVFVYDSFHNIIGYHSKNGTYYCMAPCVSVPVSVIYDKSSNSHATLYGSVACDHIKMIPSVLSRETATKLRASDNGLLQTAVGCVIGFHNTSDTVEDCNLPLGQSLCAKPPSLTRSANNTFGLAVMKYENPLKVEVLNSSEFEISVPTNFSFRVTEEFIETSIQKVTVDCKQYVCNGFERCEQLLEQYGQFCAKINQALHGVNLRQDDATKSLFESIRVPQSAPLMASLSGDYNLSLFETPSINTGGSGNYRSALEDLLFDKVTLSVPGYMKGYDECMKKGPPSARDLICAQYVAGYKVLPPLYDSNMEAMYTASLTGSIAGALWTGGLSSAASLPFAQSIYYRMNGIGITQNVLMENQKLIANKFNQALGAMQTGFTTTNQAFQKVQDAVNANAQALSKLASELSNTFGAISASIGDILKRLDTLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLVKDKVNECVKSQSSRNGFCGQGTHIVSFAVNAPNGFYFVHVGYHPTDYVNQTSAYGLCDSSNTKCIAAKNGYFIKNGSDDWMFTGSSYYQPEPITNFNSRSVEPEVTFQNLTNNLPPPLSNSTDVDFKDELEEFFKNITSEVPNFGSITQINSTVLDLSEEMKTLQSVVEALNQSYIELKELGNYTYYNKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA
Non polymer #2 FOL

InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
Non polymer #3 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference