2025-06-14_00000187|medium|9JMG

Cryo-EM structure of EU-HedgehogCoV (Erinaceus/VMC/DEU/2012) S-trimer in a locked-2 conformation; Electron microscopy 3.00Å
Protein #1 1353 residues (83% resolved)

MIRSACLLMCLLMFIKATPSEGTCISVDMQPSYFIKNWSMPINMSKADGVLYPVGRTYSNITITLEGLFPHQADRGDMYVYSQSHKGRPFISNYSLVTNDFGNGIVIRIGSAANKTGSPIISNIASNFQIMKKLYPALLFGSAVGKFPANNKTGAYFNHSLVILPEKCGTVITALYCVLEPKNDTNCTGSSGYVSYVLFENFSCDATTDGNLKNSLQQWFNIKDCLFEKNYNVTDDEREEWFGIIQDQQGVHLYTSRKNGYSNNMFLFATLPIYDQILYYTVMPRSINASNYASYHAFSAFYIYKLHKINYMVDFDVNGYITRAVDCGYNDYTQLQCSYGQFDMDSGVYSASYFNARSRGYYYEAAELTECDLDVLFKNDAPIIANYSRRVFTNCNYNLTKLLSLVQVDEFVCHKTTPEALATGCYSSLTVDWFALPFSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHAAVTANVSTALNFTANANYAYISRCQGVDGKPILLQPGQMTNIACRSGVLARPSDADYFGYSFQGRNYYLGRKSYKPKTDEGDVQMVYVITPKYDKGPDTVCPLKDMGAASSSLDGLLGQCIDYDIHGVVGRGVFQVCNTTGIASQIFVYDGFGNIIGFHSKNGTYYCMAPCVSVPVSVIYDKSSDVHATLYSSVECNHIKSVATVFSRQTESKLRSSDNGLLQTAVGCVIGFRNTSDTVEDCTLPLGQSLCAKPPSFSSRSTNVNNTFALVHMLFQNPLKVSVLNSTEFQVSIPQNFSFGITEEFIETSIQKVTVDCKQYVCNGFERCEQLLVQYGQFCSKINQALHGVNLRQDDATKSLFEDIKVPQSVPLMTSLTGDYNLSLFEAPNIGSGNNNYRSALEDLLFDKVTLSDPGYMKGYDECMKKGPPSARDLICAQYVSGYKVLPPLYDANMEAMYTASLTGSIAGSFWTGGLSSAAALPFAQSMFYRMNGIGITQNVLMKNQREIANKFNQALGAMQTGFTATNQAFQKVQDVVNANAQALSKLASELANTFGAISASIGDILKRLDVLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLAKEKINECVKAQSTRSGFCGQGTHIVSFVINAPNGFYFIHVGYHPQDYVNQTAAYGLCDSSSKKCIAAKNGYFVKNDSDSGSWSYTGSSFYQPEPITTFNSRFVEPEVTFQNLSNNLPPPLLSNNTDITFEDELEEFYKNITSEIPNFGSLSQINTTMLNLSQEMSTLQQVVKDLNNSYIELKELGNHTYYQKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA

MIRSACLLMCLLMFIKATPSEGTCISVDMQPSYFIKNWSMPINMSKADGVLYPVGRTYSNITITLEGLFPHQADRGDMYVYSQSHKGRPFISNYSLVTNDFGNGIVIRIGSAANKTGSPIISNIASNFQIMKKLYPALLFGSAVGKFPANNKTGAYFNHSLVILPEKCGTVITALYCVLEPKNDTNCTGSSGYVSYVLFENFSCDATTDGNLKNSLQQWFNIKDCLFEKNYNVTDDEREEWFGIIQDQQGVHLYTSRKNGYSNNMFLFATLPIYDQILYYTVMPRSINASNYASYHAFSAFYIYKLHKINYMVDFDVNGYITRAVDCGYNDYTQLQCSYGQFDMDSGVYSASYFNARSRGYYYEAAELTECDLDVLFKNDAPIIANYSRRVFTNCNYNLTKLLSLVQVDEFVCHKTTPEALATGCYSSLTVDWFALPFSMKSTLAIGSAEAISMFNYNQDYSNPTCRIHAAVTANVSTALNFTANANYAYISRCQGVDGKPILLQPGQMTNIACRSGVLARPSDADYFGYSFQGRNYYLGRKSYKPKTDEGDVQMVYVITPKYDKGPDTVCPLKDMGAASSSLDGLLGQCIDYDIHGVVGRGVFQVCNTTGIASQIFVYDGFGNIIGFHSKNGTYYCMAPCVSVPVSVIYDKSSDVHATLYSSVECNHIKSVATVFSRQTESKLRSSDNGLLQTAVGCVIGFRNTSDTVEDCTLPLGQSLCAKPPSFSSRSTNVNNTFALVHMLFQNPLKVSVLNSTEFQVSIPQNFSFGITEEFIETSIQKVTVDCKQYVCNGFERCEQLLVQYGQFCSKINQALHGVNLRQDDATKSLFEDIKVPQSVPLMTSLTGDYNLSLFEAPNIGSGNNNYRSALEDLLFDKVTLSDPGYMKGYDECMKKGPPSARDLICAQYVSGYKVLPPLYDANMEAMYTASLTGSIAGSFWTGGLSSAAALPFAQSMFYRMNGIGITQNVLMKNQREIANKFNQALGAMQTGFTATNQAFQKVQDVVNANAQALSKLASELANTFGAISASIGDILKRLDVLEQEVQIDRLINGRLTSLNAFVSQQLVRSEAAARSSQLAKEKINECVKAQSTRSGFCGQGTHIVSFVINAPNGFYFIHVGYHPQDYVNQTAAYGLCDSSSKKCIAAKNGYFVKNDSDSGSWSYTGSSFYQPEPITTFNSRFVEPEVTFQNLSNNLPPPLLSNNTDITFEDELEEFYKNITSEIPNFGSLSQINTTMLNLSQEMSTLQQVVKDLNNSYIELKELGNHTYYQKWPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGGGSGGSAWSHPQFEKSA
Non polymer #2 EIC

InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-

CCCCCC=C/CC=C/CCCCCCCC(=O)O
Non polymer #3 FOL

InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Download coordinates
Reference