2025-06-07_00000327|hard|9IZS

Cryo-EM structure of CasLambda2-crRNA-target DNA ternary complex in the TS-cleaving state; Electron microscopy 2.84Å
Protein #1 751 residues (98% resolved)

MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWKDKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTSEDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQHINSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYELEKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFARYNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKESMDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHKLENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQIALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYNVPSLDTTKKGPSAILHMLKKIEAIKILETEK

MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWKDKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTSEDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQHINSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYELEKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFARYNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKESMDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHKLENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQIALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYNVPSLDTTKKGPSAILHMLKKIEAIKILETEK
RNA #2 58 bases

GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC

GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC
DNA #3 15 bases

(DT)(DG)(DT)(DC)(DT)(DA)(DT)(DT)(DT)(DA)(DG)(DG)(DA)(DG)(DA)

TGTCTATTTAGGAGA
DNA #4 40 bases

(AS)(PST)(AS)(PST)(GS)(AS)(PST)(GS)(GS)(PST)(GS)(SC)(DC)(DA)(DC)(DG)(DC)(DG)(DC)(DA)(DC)(DC)(DT)(DC)(DA)(DT)(DC)(DT)(DC)(DC)(DT)(DA)(DA)(DA)(DT)(DA)(DG)(DA)(DC)(DA)

ATATGATGGTGCCACGCGCACCTCATCTCCTAAATAGACA
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
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Reference