2025-06-07_00000324|hard|9IZP

Cryo-EM structure of CasLambda2-crRNA-target DNA ternary complex in the incompetent state; Electron microscopy 2.89Å
Protein #1 751 residues (84% resolved)

MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWKDKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTSEDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQHINSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYELEKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFARYNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKESMDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHKLENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQIALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYNVPSLDTTKKGPSAILHMLKKIEAIKILETEK

MGHHHHHHGGMKKSIKFKVKGNCPITKDVINEYKEYYNKCSDWIKNNLTSITIGEMAKFLQETLGKDVAYISMGLSDEWKDKPLYHLFTKKYHTNNADNLLYYYIKEKNLDGYKGNTLNIGNTFFRQFGYFKLVVSNYRTKIRTLNCEIKRKKIDADSTSEDIEMQTMYEIIKHNLNKKTDWDEFISYIENVENPNIDNINRYKLLRKCFCENENMIKNKLELLSIEQLKNFGGCIMKQHINSMTLIIQHFKIEEKENSLGFILNLPLNKKQYQIELWGNRQVNKGTKERDAFLNTYGENIVFIINNDELYVVFSYEYELEKEEANFVKTVGLDVNFKHAFFVTSEKDNCHLDGYINLYKYLLEHDEFTNLLTNDEKKDYEELSKVVTFCPFENQLLFARYNKMSKFCKKEQVLSKLLYALQKQLKDENRTKEYIYVSCVNKLRAKYVSYFILKEKYYEKQKEYDIEMGFVDDSTESKESMDKRRTEFPFRNTPVANELLSKLNNVQQDINGCLKNIINYIYKIFEQNGYKIVALENLENSNFEKKQVLPTIKSLLKYHKLENQNVNDIKASDKVKEYIENGYYELITNENNEIVDAKYTEKGAMKVKNANFFNLMMKSLHFASVKDEFVLLSNNGKTQIALVPSEFTSQMDSTDHCLYMKKNDKGKLVKADKKEVRTKQEKHINGLNADFNAANNIKYIVENEVWREIFCTRPKKAEYNVPSLDTTKKGPSAILHMLKKIEAIKILETEK
RNA #2 58 bases

GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC

GGCUUGUUGUAUAUAUUCUUUUAUAGGUAUUAAACAACGGAGAUGAGGUGCGCGUGGC
DNA #3 40 bases

(DT)(DG)(DT)(DC)(DT)(DA)(DT)(DT)(DT)(DA)(DG)(DG)(DA)(DG)(DA)(DT)(DG)(DA)(DG)(DG)(DT)(DG)(DC)(DG)(DC)(DG)(DT)(DG)(GS)(SC)(AS)(SC)(SC)(AS)(PST)(SC)(AS)(PST)(AS)(PST)

TGTCTATTTAGGAGATGAGGTGCGCGTGGCACCATCATAT
DNA #4 40 bases

(AS)(PST)(AS)(PST)(GS)(AS)(PST)(GS)(GS)(PST)(GS)(SC)(DC)(DA)(DC)(DG)(DC)(DG)(DC)(DA)(DC)(DC)(DT)(DC)(DA)(DT)(DC)(DT)(DC)(DC)(DT)(DA)(DA)(DA)(DT)(DA)(DG)(DA)(DC)(DA)

ATATGATGGTGCCACGCGCACCTCATCTCCTAAATAGACA
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
Download coordinates
Reference