2025-05-31_00000191|ligand|9HL6

TRPML1 in complex with compound 4a; Electron microscopy 2.20Å
Protein #1 628 residues (73% resolved)

MHHHHHHHHGGSDYKDHDGDYKDHDIDYKDDDDKGGSGGSENLYFQGPGTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN

MHHHHHHHHGGSDYKDHDGDYKDHDIDYKDDDDKGGSGGSENLYFQGPGTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN
Non polymer #2 A1IV1

InChI=1S/C28H31ClFN3O4S2/c1-28(20-14-16-32(17-15-20)27-13-8-21(29)18-25(27)30)19-33(26-7-5-4-6-24(26)28)39(36,37)23-11-9-22(10-12-23)38(34,35)31(2)3/h4-13,18,20H,14-17,19H2,1-3H3/t28-/m1/s1

C[C@@]1(CN(c2c1cccc2)S(=O)(=O)c3ccc(cc3)S(=O)(=O)N(C)C)C4CCN(CC4)c5ccc(cc5F)Cl
Non polymer #3 EUJ

InChI=1S/C25H49O19P3/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-25-21(29)23(42-45(31,32)33)20(28)24(22(25)30)43-46(34,35)36/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36)/t17-,20-,21-,22-,23-,24+,25-/m1/s1

CCCCCCCC(=O)OC[C@H](COP(=O)(O)OC1[C@@H]([C@H](C([C@H]([C@H]1O)OP(=O)(O)O)O)OP(=O)(O)O)O)OC(=O)CCCCCCC
Non polymer #4 HEX

InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3

CCCCCC
Non polymer #5 LNK

InChI=1S/C5H12/c1-3-5-4-2/h3-5H2,1-2H3

CCCCC
Non polymer #6 OCT

InChI=1S/C8H18/c1-3-5-7-8-6-4-2/h3-8H2,1-2H3

CCCCCCCC
Non polymer #7 R16

InChI=1S/C16H34/c1-3-5-7-9-11-13-15-16-14-12-10-8-6-4-2/h3-16H2,1-2H3

CCCCCCCCCCCCCCCC
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Reference